Mitochondrial replacement therapy - a solution to harmful genes or a potential problem in itself?

Mitochondrial replacement therapy aims to aims to prevent mothers from passing on harmful genes to children through their mitochondria, but research suggests this therapy could backfire. Find out more about this research:

Articles

• Three-person embryos may fail to vanquish mutant mitochondria - article in Nature magazine.
• mtDNA Segregation in Heteroplasmic Tissues Is Common In Vivo and Modulated by Haplotype Differences and Developmental Stage - article on Science Direct

Papers

• Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism - paper published with eLife