A review of Suzuki-Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates is published

Joshua Almond-Thynne David C. Blakemore, David C. Pryde and Alan C. Spivey, 'Site-selective Suzuki-Miyaura Coupling of Heteroaryl Halides - Understanding the Trends for Pharmaceutically Important Cases', Chem. Sci. 2017, 8, 40 - 62. DOI: 10.1039/C6SC02118B

Suzuki-Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources as well as bespoke searches of Pfizer’s global chemistry RKB and CAS Scifinder® databases, the factors that determine the site-selectivity of these reactions are discussed with a view to rationalising the trends found.