Oxytocin and vasopressin analogs, and elucidating the role of EspJ

Congratulations to Rhiannon on her recent paper!

Rhiannon's paper 'Building bridges for highly selective, potent and stable oxytocin and vasopressin analogs' covers work completed during her PhD in the Tate Group. The report describes the synthesis and testing of new analogues of the nona-peptide oxytocin, which displayed favourable selectivity and potency as well as increased stability at higher temperatures. 

There was also a new publication in April with scientists from Prof. Gad Frankel's research group at the MRC Centre for Molecular Bacteriology and Infection and researchers from the Institute for Cancer Research. The collaboration, including Tate Group member Kate Hadavizadeh, aimed to elucidate the role of ADP-ribosyltransferase effector EspJ and demonstrated the use of proteomics to study in vivo processes affected by a type III secretion system.