Dr Nick Jones publishes paper in Nature Communications

Dr Nick Jones

Congratulations to Dr Nick Jones on the recent publication in Nature Communications.

Dr Nick Jones, from the Department of Mathematics and EPSRC Centre for Mathematics of Precision Healthcare, has co-authored a paper in Nature Communications entitled ‘High prevalence of focal and multi-focal somatic genetic variants in the human brain', which explores direct evidence for large islands of mutation in the brain using deep-sequencing of aggregates of cells.

Dr Nick Jones and collaborators harnessed ultra-high depth sequencing to survey the somatic mutations across different brain regions. Using a computational model of brain development, they extrapolate their findings across the human brain, and provide an estimate of the somatic mutation burden in the human population. Read the paper in Nature Communications here.