A short review of the importance and utility of ortho-Quinone Methides as reactive intermediates in synthesis is presented.

Chris D-T. Nielsen, Hossay Abas, Alan C. Spivey 'Stereoselective reactions of ortho-quinone methide and ortho-quinone methide imines and their utility in natural product synthesis' Synthesis, 2018, 50, 4008-4018 DOI: 10.1055/s-0037-1610241

This article provides a review of the reactivity and synthetic utility of ortho quinone methide and ortho quinone methide imines. These versatile intermediates have received significant attention in the literature and new methods for their preparation and reaction as well as recent applications in total synthesis are discussed