Dr Janine Gray presented at the RSC Biological and Medicinal Chemistry Sector (BMCS) symposium and won the runner-up prize for best oral presentation.
The presentation highlighted current research, in collaboration with the Edwards lab from the Department of Infectious Disease, to identify novel compounds to tackle antimicrobial resistance (AMR). Following a high-throughput screen to identify compounds which inhibit a key bacterial DNA repair pathway, potent inhibitors were discovered that re-sensitised methicillin-resistant S. aureus (MRSA) to the antibiotic ciprofloxacin. Ongoing medicinal chemistry efforts in the group have established compounds with potent activity in both in vitro and in vivo models.
Congratulations Janine on her presentation prize!
This research was funded by the Rosetrees Trust and an UKRI Impact Acceleration Award.
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Edward Bartlett
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