CRISPR‐TAPE
CRISPR‐TAPE: protein‐centric CRISPR guide design
Protein‐centric CRISPR guide design has been developed for targeted proteome engineering
Stories written by Ravi Singh
Peptide probes
Peptide probes for Plasmodium falciparum MTIP
Peptide-based probes demonstrate low nanomolar binding affinity and enhanced cell penetration
NMT inhibitors
N-myristoyltransferase inhibitors against wheat pathogen Zymoseptoria tritici
N-myristoyltransferase inhibitors display on-target antifungal activity and reveal an unusual metabolic defence mechanism
Antibody PROTAC
A new antibody-PROTAC combination can selectively target Breast Cancer cells
A new antibody-PROTAC combination can selectively target Breast Cancer cells, and then degrade the protein inside
Light mediated PROTACs
A caged E3 ligase ligand for PROTAC-mediated protein degradation
Photocaged PROTACs allow for the controlled release of the PROTAC
DUB inhibitors
Re-evaluating the mechanism of action of DUB inhibitors
DUB inhibitors found to induce non-specific protein aggregation
Colitis severity
Faecal neutrophil elastase-antiprotease and its activity on colitis severity
New collaborative research has identified a biomarker, and potential treatment target, for colitis.
Jasmine defends thesis
Congratulations Jasmine!
Congratulations to Imperial student Jasmine who successfully defended her PhD thesis this week!
