@article{Garcia:2016:10.1038/srep23590,
author = {Garcia, E and Ragazzini, C and Yu, X and Cuesta-Garcia, E and Bernardino, de la Serna J and Zech, T and Sarrio, D and Machesky, LM and Anton, IM},
doi = {10.1038/srep23590},
journal = {Scientific Reports},
title = {WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion},
url = {http://dx.doi.org/10.1038/srep23590},
volume = {6},
year = {2016}
}

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TY  - JOUR
AB  - Cancer cells form actin-rich degradative protrusions (invasive pseudopods and invadopodia), whichallows their efficient dispersal during metastasis. Using biochemical and advanced imaging approaches,we demonstrate that the N-WASP-interactors WIP and WICH/WIRE play non-redundant roles incancer cell invasion. WIP interacts with N-WASP and cortactin and is essential for invadopodiumassembly, whereas WICH/WIRE regulates N-WASP activation to control invadopodium maturationand degradative activity. Our data also show that Nck interaction with WIP and WICH/WIRE modulatesinvadopodium maturation; changes in WIP and WICH/WIRE levels induce differential distribution ofNck. We show that WIP can replace WICH/WIRE functions and that elevated WIP levels correlate withhigh invasiveness. These findings identify a role for WICH/WIRE in invasiveness and highlight WIP asa hub for signaling molecule recruitment during invadopodium generation and cancer progression, aswell as a potential diagnostic biomarker and an optimal target for therapeutic approaches.
AU  - Garcia,E
AU  - Ragazzini,C
AU  - Yu,X
AU  - Cuesta-Garcia,E
AU  - Bernardino,de la Serna J
AU  - Zech,T
AU  - Sarrio,D
AU  - Machesky,LM
AU  - Anton,IM
DO  - 10.1038/srep23590
PY  - 2016///
SN  - 2045-2322
TI  - WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/srep23590
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000372698800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/69268
VL  - 6
ER  - 

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