@article{Sharanya:2019:10.1177/1479973119843650,
author = {Sharanya, A and Ciano, M and Withana, S and Polkey, M and Kemp, P and Natanek, S},
doi = {10.1177/1479973119843650},
journal = {Chronic Respiratory Disease},
pages = {1--13},
title = {Sex differences in COPD-related quadriceps muscle dysfunction and fibre abnormalities},
url = {http://dx.doi.org/10.1177/1479973119843650},
volume = {16},
year = {2019}
}

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TY  - JOUR
AB  - Background: In COPD, lower limb dysfunction is associated with reduced exercise capacity, increased hospitalisations and mortality. We investigated sex differences in the prevalence of quadriceps dysfunction and fibre abnormalities in a large COPD cohort, controlling for the normal sex differences in health. Methods: We compared existing data from 76 male and 38 female COPD patients where each variable was expressed as a function of gender-specific normal values (obtained from 16 male and 14 female controls). Results: Female COPD patients had lower quadriceps muscle strength and peak workload on a maximal incremental cycle ergometry protocol compared to male patients. Female patients had a smaller type II fibre cross-sectional area (CSA) compared to male patients, suggesting a greater female preponderance to fibre atrophy, although this result was largely driven by a few male patients with increased type II fibre CSA. Female patients had significantly higher concentrations of a number of plasma pro-inflammatory cytokines including tumor necrosis factor alpha (TNFα) and interleukin 8 (IL8), but not lower levels of physical activity or arterial oxygenation, compared to males. Conclusions: Our data confirms results from a previous small study and suggests that female COPD patients have a greater prevalence of muscle wasting and weakness. Larger studies investigating sex differences in COPD-related muscle atrophy and weakness are needed, as the results will have implications for monitoring in clinical practice and for design of clinical trials evaluating novel muscle anabolic agents.
AU  - Sharanya,A
AU  - Ciano,M
AU  - Withana,S
AU  - Polkey,M
AU  - Kemp,P
AU  - Natanek,S
DO  - 10.1177/1479973119843650
EP  - 13
PY  - 2019///
SN  - 1479-9723
SP  - 1
TI  - Sex differences in COPD-related quadriceps muscle dysfunction and fibre abnormalities
T2  - Chronic Respiratory Disease
UR  - http://dx.doi.org/10.1177/1479973119843650
UR  - https://journals.sagepub.com/doi/10.1177/1479973119843650#
UR  - http://hdl.handle.net/10044/1/68707
VL  - 16
ER  - 

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