BibTex format
@article{Martinez:2018:10.1164/rccm.201710-2028PP,
author = {Martinez, F and Han, M and Allinson, J and Barr, G and Boucher, R and Calverley, PMA and Celli, BR and Christenson, SA and Crystal, RG and Fageras, M and Freeman, CM and Groenke, L and Hoffman, EA and Kesimer, M and Kostikas, K and Paine, III R and Rafii, S and Rennard, SI and Segal, LN and Shaykhiev, R and Stevenson, C and Ruth, T-S and Vestbo, J and Woodruff, P and Curtis, J and Wedzicha, J},
doi = {10.1164/rccm.201710-2028PP},
journal = {American Journal of Respiratory and Critical Care Medicine},
pages = {1540--1551},
title = {At the root: defining and halting progression of early chronic obstructive pulmonary disease},
url = {http://dx.doi.org/10.1164/rccm.201710-2028PP},
volume = {197},
year = {2018}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Chronic obstructive pulmonary disease (COPD) is a prevalent, heterogeneous disorder with varying presentation and progression but with a limited number of disease-modifying therapies (1). This marked heterogeneity impedes identification of subpopulations at risk for accelerated progression, thwarting therapeutic advances. Most COPD studies have included populations with mean ages older than 60 years (2). However, it is increasingly evident that lung function trajectories in COPD differ significantly and that differences are detectable in young adulthood (3–5). In this Perspective, we highlight the need to distinguish “early disease” from late “mild disease,” propose an operational definition of early COPD for use in research studies, and attempt to unify current views on potential disease mechanisms. We focus on smoking, the chief etiologic factor for COPD in the industrialized world. Whether pathogenic mechanisms and effective treatments are shared with the sizable fraction of COPD in never-smokers or resulting from biomass fuel, electronic nicotine delivery systems, and other exposures, are separate, significant questions. We argue that refocusing investigation on early COPD could revolutionize understanding and therapies of this leading cause of worldwide death.
AU - Martinez,F
AU - Han,M
AU - Allinson,J
AU - Barr,G
AU - Boucher,R
AU - Calverley,PMA
AU - Celli,BR
AU - Christenson,SA
AU - Crystal,RG
AU - Fageras,M
AU - Freeman,CM
AU - Groenke,L
AU - Hoffman,EA
AU - Kesimer,M
AU - Kostikas,K
AU - Paine,III R
AU - Rafii,S
AU - Rennard,SI
AU - Segal,LN
AU - Shaykhiev,R
AU - Stevenson,C
AU - Ruth,T-S
AU - Vestbo,J
AU - Woodruff,P
AU - Curtis,J
AU - Wedzicha,J
DO - 10.1164/rccm.201710-2028PP
EP - 1551
PY - 2018///
SN - 1073-449X
SP - 1540
TI - At the root: defining and halting progression of early chronic obstructive pulmonary disease
T2 - American Journal of Respiratory and Critical Care Medicine
UR - http://dx.doi.org/10.1164/rccm.201710-2028PP
UR - http://hdl.handle.net/10044/1/56878
VL - 197
ER -