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@article{Ciaccio:2018:10.1016/j.compbiomed.2018.07.020,
author = {Ciaccio, EJ and Peters, NS and Garan, H},
doi = {10.1016/j.compbiomed.2018.07.020},
journal = {Computers in Biology and Medicine},
pages = {357--368},
title = {Use of an automaton model to suggest methods for cessation of intractable fibrillatory activity},
url = {http://dx.doi.org/10.1016/j.compbiomed.2018.07.020},
volume = {102},
year = {2018}
}
TY - JOUR
AB - BACKGROUND: Atrial fibrillation (AF) is the most common heart arrhythmia, and permanent AF is an intractable medical problem. If cessation of permanent AF were possible, via extensive substrate ablation or multisite stimulation, it could significantly improve the public health. METHOD: A cellular automaton composed of 576×576 computerized grid nodes, described in detail previously, was used to test hypotheses concerning the cessation of fibrillatory electrical activity. A refractory period gradient across the grid, and addition of randomly located nonconducting fibers, were utilized as conditions leading to fibrillatory activity. A premature S1-S2 stimulus was applied to one grid corner, resulting in unidirectional conduction block at some locations, followed by rotational activity and random propagation of activation wavelets throughout the grid, none of which terminated spontaneously. Simulated ablation lesions of dimension 20×20 grid nodes, imparted at core locations of rotational activity, and multisite electrode stimulation (MES) applied at nodes where recovery of excitability had occurred, were used in attempts to terminate fibrillatory activity. Six impositions of random fiber location were utilized in separate trials. RESULTS: Simulated ablation lesions eliminated the targeted swirling vortices; however, additional vortices then often appeared at other locations. After ablating approximately one third of the grid area, localized vortices were eliminated, but individual wavelets continued to propagate about longer viable pathways forming at ablation lesions. Thus extensive ablation was unsuccessful in terminating arrhythmia. However, MES applied uniformly throughout the grid, with a coupling interval slightly longer than the maximum refractory period, terminated fibrillatory activity in some trials. More efficaciously, application of MES with a coupling interval half the maximum refractory period of the grid succeeded in capture of activation
AU - Ciaccio,EJ
AU - Peters,NS
AU - Garan,H
DO - 10.1016/j.compbiomed.2018.07.020
EP - 368
PY - 2018///
SN - 0010-4825
SP - 357
TI - Use of an automaton model to suggest methods for cessation of intractable fibrillatory activity
T2 - Computers in Biology and Medicine
UR - http://dx.doi.org/10.1016/j.compbiomed.2018.07.020
UR - https://www.ncbi.nlm.nih.gov/pubmed/30097173
UR - http://hdl.handle.net/10044/1/62676
VL - 102
ER -