In this section
@article{Ciaccio:2018:10.1016/j.jacep.2017.08.019,
author = {Ciaccio, EJ and Coromilas, J and Wit, AL and Peters, NS and Garan, H},
doi = {10.1016/j.jacep.2017.08.019},
journal = {JACC: Clinical Electrophysiology},
pages = {1--16},
title = {Source-sink mismatch causing functional conduction block in re-entrant ventricular tachycardia},
url = {http://dx.doi.org/10.1016/j.jacep.2017.08.019},
volume = {4},
year = {2018}
}
TY - JOUR
AB - Ventricular tachycardia (VT) caused by a re-entrant circuit is a life-threatening arrhythmia that at present cannot always be treated adequately. A realistic model of re-entry would be helpful to accurately guide catheter ablation for interruption of the circuit. In this review, models of electrical activation wavefront propagation during onset and maintenance of re-entrant VT are discussed. In particular, the relationship between activation mapping and maps of transition in infarct border zone thickness, which results in source-sink mismatch, is considered in detail and supplemented with additional data. Based on source-sink mismatch, the re-entry isthmus can be modeled from its boundary properties. Isthmus boundary segments with large transitions in infarct border zone thickness have large source-sink mismatch, and functional block forms there during VT. These alternate with segments having lesser thickness change and therefore lesser source-sink mismatch, which act as gaps, or entrance and exit points, to the isthmus during VT. Besides post-infarction substrates, the source-sink model is likely applicable to other types of volumetric changes in the myocardial conducting medium, such as when there is presence of fibrosis or dissociation of muscle fibers.
AU - Ciaccio,EJ
AU - Coromilas,J
AU - Wit,AL
AU - Peters,NS
AU - Garan,H
DO - 10.1016/j.jacep.2017.08.019
EP - 16
PY - 2018///
SN - 2405-5018
SP - 1
TI - Source-sink mismatch causing functional conduction block in re-entrant ventricular tachycardia
T2 - JACC: Clinical Electrophysiology
UR - http://dx.doi.org/10.1016/j.jacep.2017.08.019
UR - https://www.ncbi.nlm.nih.gov/pubmed/29600773
UR - http://hdl.handle.net/10044/1/59909
VL - 4
ER -