@article{Jenab:2010:10.1136/bmj.b5500,
author = {Jenab, M and Bueno-de-Mesquita, HB and Ferrari, P and van, Duijnhoven FJB and Norat, T and Pischon, T and Jansen, EHJM and Slimani, N and Byrnes, G and Rinaldi, S and Tjonneland, A and Olsen, A and Overvad, K and Boutron-Ruault, M-C and Clavel-Chapelon, F and Morois, S and Kaaks, R and Linseisen, J and Boeing, H and Bergmann, MM and Trichopoulou, A and Misirli, G and Trichopoulos, D and Berrino, F and Vineis, P and Panico, S and Palli, D and Tumino, R and Ros, MM and van, Gils CH and Peeters, PH and Brustad, M and Lund, E and Tormo, M-J and Ardanaz, E and Rodriguez, L and Sanchez, M-J and Dorronsoro, M and Gonzalez, CA and Hallmans, G and Palmqvist, R and Roddam, A and Key, TJ and Khaw, K-T and Autier, P and Hainaut, P and Riboli, E},
doi = {10.1136/bmj.b5500},
journal = {British Medical Journal},
title = {Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations: a nested case-control study},
url = {http://dx.doi.org/10.1136/bmj.b5500},
volume = {340},
year = {2010}
}

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TY  - JOUR
AB  - Objective To examine the association between pre-diagnostic circulating vitamin D concentration, dietary intake of vitamin D and calcium, and the risk of colorectal cancer in European populations.Design Nested case-control study.Setting The study was conducted within the EPIC study, a cohort of more than 520 000 participants from 10 western European countries.Participants 1248 cases of incident colorectal cancer, which developed after enrolment into the cohort, were matched to 1248 controlsMain outcome measures Circulating vitamin D concentration (25-hydroxy-vitamin-D, 25-(OH)D) was measured by enzyme immunoassay. Dietary and lifestyle data were obtained from questionnaires. Incidence rate ratios and 95% confidence intervals for the risk of colorectal cancer by 25-(OH)D concentration and levels of dietary calcium and vitamin D intake were estimated from multivariate conditional logistic regression models, with adjustment for potential dietary and other confounders.Results 25-(OH)D concentration showed a strong inverse linear dose-response association with risk of colorectal cancer (P for trend <0.001). Compared with a pre-defined mid-level concentration of 25-(OH)D (50.0-75.0 nmol/l), lower levels were associated with higher colorectal cancer risk (<25.0 nmol/l: incidence rate ratio 1.32 (95% confidence interval 0.87 to 2.01); 25.0-49.9 nmol/l: 1.28 (1.05 to 1.56), and higher concentrations associated with lower risk (75.0-99.9 nmol/l: 0.88 (0.68 to 1.13); ≥100.0 nmol/l: 0.77 (0.56 to 1.06)). In analyses by quintile of 25-(OH)D concentration, patients in the highest quintile had a 40% lower risk of colorectal cancer than did those in the lowest quintile (P<0.001). Subgroup analyses showed a strong association for colon but not rectal cancer (P for heterogeneity=0.048). Greater dietary intake of calcium was associated with a lower colorectal cancer risk. Dietary vitamin D was not associated with disease risk. Findings did not vary by sex and were n
AU  - Jenab,M
AU  - Bueno-de-Mesquita,HB
AU  - Ferrari,P
AU  - van,Duijnhoven FJB
AU  - Norat,T
AU  - Pischon,T
AU  - Jansen,EHJM
AU  - Slimani,N
AU  - Byrnes,G
AU  - Rinaldi,S
AU  - Tjonneland,A
AU  - Olsen,A
AU  - Overvad,K
AU  - Boutron-Ruault,M-C
AU  - Clavel-Chapelon,F
AU  - Morois,S
AU  - Kaaks,R
AU  - Linseisen,J
AU  - Boeing,H
AU  - Bergmann,MM
AU  - Trichopoulou,A
AU  - Misirli,G
AU  - Trichopoulos,D
AU  - Berrino,F
AU  - Vineis,P
AU  - Panico,S
AU  - Palli,D
AU  - Tumino,R
AU  - Ros,MM
AU  - van,Gils CH
AU  - Peeters,PH
AU  - Brustad,M
AU  - Lund,E
AU  - Tormo,M-J
AU  - Ardanaz,E
AU  - Rodriguez,L
AU  - Sanchez,M-J
AU  - Dorronsoro,M
AU  - Gonzalez,CA
AU  - Hallmans,G
AU  - Palmqvist,R
AU  - Roddam,A
AU  - Key,TJ
AU  - Khaw,K-T
AU  - Autier,P
AU  - Hainaut,P
AU  - Riboli,E
DO  - 10.1136/bmj.b5500
PY  - 2010///
SN  - 1468-5833
TI  - Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations: a nested case-control study
T2  - British Medical Journal
UR  - http://dx.doi.org/10.1136/bmj.b5500
UR  - http://hdl.handle.net/10044/1/28217
VL  - 340
ER  - 

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