Apoorva Srivastava

Apoorva started her research career with a master's in Organic Chemistry, followed by a PhD under the guidance of Professor Geert Jan Boons in University of Georgia (USA) and Utrecht University (The Netherlands). In the Boons group, she worked on the chemo-enzymatic synthesis of human and parasitic N-glycans and their effects on immunomodulatory proteins. After a short industrial stint where she worked on the synthesis of novel drug candidates pertaining to small molecules as well as sugars, she joined Imperial College in July 2022 as a Post-Doctoral Research Associate with Dr Benjamin Schumann in the Department of Chemistry, where she will work on various chemo-enzymatic and chemical biology techniques to understand the physiological roles of carbohydrates. In a joint collaboration with the Glycoscience laboratory lead by Prof. Ten Feizi and Dr. Yan Liu, she is also a member of the Carbohydrate Microarray Facility supported by Wellcome Trust where she will be involved in the design and expansion of carbohydrate recognizing probes in micro-array studies. Publications: A.D. Srivastava, L. Unione, M. Bunyatov, I.A. Gagarinov, N.G.A. Abrescia, S. Delgado, A. Ardá and G.J. Boons. Chemoenzymatic synthesis of complex N-glycans of the parasite S. mansoni to examine the importance of epitope presentation on DC-SIGN recognition. 2021, Angew. Chem. Int. Ed., 60, 19287-19296. DOI A.D. Srivastava, L. Unione, P. Valverde, M.A. Wolfert, A. Ardá, J. Jiménez-Barbero and G.J. Boons. Mono- and Di-Fucosylated glycans of the parasitic worm S. mansoni are recognized differently by the innate immune receptor DC-SIGN. 2020, Chem. Eur. J., 26, 15605-15612. DOI Sastre-Toraño, I.A. Gagarinov, G.M. Vos, F. Broszeit, A.D. Srivastava, M. Palmer, J.I. Langridge, O. Aizpurua-Olaizola, V.J. Somovilla, and G.J. Boons. Ion-mobility spectrometry can assign exact fucosyl positions in glycans and prevent misinterpretation of mass spectrometry data after gas-phase rearrangement. 2019, Angew. Chem. Int. Ed.,58(49), 17616-17620. DOI I.A. Gagarinov, T. Li, J. Sastre Torano, T. Caval, A.D. Srivastava, J.A.W. Kruijtzer, A.J.R. Heck and G.J. Boons. Chemoenzymatic Approach for the Preparation of Asymmetric bi-, tri- and tetra-antennary N-Glycans from a common precursor. 2017, J. Am. Chem. Soc., 139(2), 1011-1018. DOI I.A. Gagarinov, T. Fang, L. Liu, A.D. Srivastava and G.J. Boons. Synthesis of Staphylococcus Aureus Type 5 Trisachharide Repeating Unit: Solving the problem of Lactamization. 2015, Org. Lett., 17(4), 928-931. DOI I.A. Gagarinov, A.D. Srivastava, G.J. Boons and Z. Wang. 2017. A multigram synthesis of phenyl 2-azido-3-O-benzyl-2-deoxy-4,6-O-benzylidene-1-thio-α-D-mannopyranoside. 2017, (Chapter 21), Carbohydrate Chemistry: Proven Synthetic Methods, Volume 4 (C. Vogel and P. Murphy, eds). I.A. Gagarinov, S. Visansirikul, A.D. Srivastava and G.J. Boons. Simplifying access to 3,4-di-O-acetyl-D-fucal 2017, (Chapter 24), Carbohydrate Chemistry: Proven Synthetic Methods, Volume 4 (C. Vogel and P. Murphy, eds).

• Faculty of Natural Sciences