Imperial College London
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Professor Christl Donnelly CBE FMedSci FRS

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

c.donnelly Website

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cho:2023:brain/awac332,
author = {Cho, S-M and White, N and Premraj, L and Battaglini, D and Fanning, J and Suen, J and Bassi, GL and Fraser, J and Robba, C and Griffee, M and Singh, B and Citarella, BW and Merson, L and Solomon, T and Thomson, D and ISARIC, Clinical Characterisation Group},
doi = {brain/awac332},
journal = {Brain},
pages = {1648--1661},
title = {Neurological manifestations of COVID-19 in adults and children},
url = {http://dx.doi.org/10.1093/brain/awac332},
volume = {146},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Different neurological manifestations of coronavirus disease 2019 (COVID-19) in adults and children and their impact have not been well characterized. We aimed to determine the prevalence of neurological manifestations and in-hospital complications among hospitalized COVID-19 patients and ascertain differences between adults and children. We conducted a prospective multicentre observational study using the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) cohort across 1507 sites worldwide from 30 January 2020 to 25 May 2021. Analyses of neurological manifestations and neurological complications considered unadjusted prevalence estimates for predefined patient subgroups, and adjusted estimates as a function of patient age and time of hospitalization using generalized linear models. Overall, 161 239 patients (158 267 adults; 2972 children) hospitalized with COVID-19 and assessed for neurological manifestations and complications were included. In adults and children, the most frequent neurological manifestations at admission were fatigue (adults: 37.4%; children: 20.4%), altered consciousness (20.9%; 6.8%), myalgia (16.9%; 7.6%), dysgeusia (7.4%; 1.9%), anosmia (6.0%; 2.2%) and seizure (1.1%; 5.2%). In adults, the most frequent in-hospital neurological complications were stroke (1.5%), seizure (1%) and CNS infection (0.2%). Each occurred more frequently in intensive care unit (ICU) than in non-ICU patients. In children, seizure was the only neurological complication to occur more frequently in ICU versus non-ICU (7.1% versus 2.3%, P < 0.001). Stroke prevalence increased with increasing age, while CNS infection and seizure steadily decreased with age. There was a dramatic decrease in stroke over time during the pandemic. Hypertension, chronic neurological disease and the use of extracorporeal membrane oxygenation were associated with increased risk of stroke. Altered consciousness was associated with CNS infection, seizure and stroke.
AU  - Cho,S-M
AU  - White,N
AU  - Premraj,L
AU  - Battaglini,D
AU  - Fanning,J
AU  - Suen,J
AU  - Bassi,GL
AU  - Fraser,J
AU  - Robba,C
AU  - Griffee,M
AU  - Singh,B
AU  - Citarella,BW
AU  - Merson,L
AU  - Solomon,T
AU  - Thomson,D
AU  - ISARIC,Clinical Characterisation Group
DO  - brain/awac332
EP  - 1661
PY  - 2023///
SN  - 1460-2156
SP  - 1648
TI  - Neurological manifestations of COVID-19 in adults and children
T2  - Brain
UR  - http://dx.doi.org/10.1093/brain/awac332
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36087305
UR  - https://academic.oup.com/brain/article/146/4/1648/6695387
UR  - http://hdl.handle.net/10044/1/105209
VL  - 146
ER  -
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