Imperial College London
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Professor Christl Donnelly CBE FMedSci FRS

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

c.donnelly Website

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wainstein:2023:10.1016/j.ekir.2023.05.015,
author = {Wainstein, M and Spyrison, N and Dai, D and Ghadimi, M and Chávez-Iñiguez, JS and Rizo-Topete, L and Citarella, BW and Merson, L and Pole, JD and Claure-Del, Granado R and Johnson, DW and Shrapnel, S and ISARIC, Characterization Group},
doi = {10.1016/j.ekir.2023.05.015},
journal = {Kidney Int Rep},
pages = {1514--1530},
title = {Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19.},
url = {http://dx.doi.org/10.1016/j.ekir.2023.05.015},
volume = {8},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - INTRODUCTION: Acute kidney injury (AKI) has been identified as one of the most common and significant problems in hospitalized patients with COVID-19. However, studies examining the relationship between COVID-19 and AKI in low- and low-middle income countries (LLMIC) are lacking. Given that AKI is known to carry a higher mortality rate in these countries, it is important to understand differences in this population. METHODS: This prospective, observational study examines the AKI incidence and characteristics of 32,210 patients with COVID-19 from 49 countries across all income levels who were admitted to an intensive care unit during their hospital stay. RESULTS: Among patients with COVID-19 admitted to the intensive care unit, AKI incidence was highest in patients in LLMIC, followed by patients in upper-middle income countries (UMIC) and high-income countries (HIC) (53%, 38%, and 30%, respectively), whereas dialysis rates were lowest among patients with AKI from LLMIC and highest among those from HIC (27% vs. 45%). Patients with AKI in LLMIC had the largest proportion of community-acquired AKI (CA-AKI) and highest rate of in-hospital death (79% vs. 54% in HIC and 66% in UMIC). The association between AKI, being from LLMIC and in-hospital death persisted even after adjusting for disease severity. CONCLUSIONS: AKI is a particularly devastating complication of COVID-19 among patients from poorer nations where the gaps in accessibility and quality of healthcare delivery have a major impact on patient outcomes.
AU  - Wainstein,M
AU  - Spyrison,N
AU  - Dai,D
AU  - Ghadimi,M
AU  - Chávez-Iñiguez,JS
AU  - Rizo-Topete,L
AU  - Citarella,BW
AU  - Merson,L
AU  - Pole,JD
AU  - Claure-Del,Granado R
AU  - Johnson,DW
AU  - Shrapnel,S
AU  - ISARIC,Characterization Group
DO  - 10.1016/j.ekir.2023.05.015
EP  - 1530
PY  - 2023///
SP  - 1514
TI  - Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19.
T2  - Kidney Int Rep
UR  - http://dx.doi.org/10.1016/j.ekir.2023.05.015
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37360820
VL  - 8
ER  -
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