Imperial College London
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Professor Christl Donnelly CBE FMedSci FRS

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

c.donnelly Website

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Whitaker:2023:10.1038/s41467-023-40643-w,
author = {Whitaker, M and Davies, B and Atchison, C and Barclay, W and Ashby, D and Darzi, A and Riley, S and Cooke, G and Donnelly, C and Chadeau, M and Elliott, P and Ward, H},
doi = {10.1038/s41467-023-40643-w},
journal = {Nature Communications},
title = {SARS-CoV-2 rapid antibody test results and subsequent risk of hospitalisation and death in 361,801 people},
url = {http://dx.doi.org/10.1038/s41467-023-40643-w},
volume = {14},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The value of SARS-CoV-2 lateral flow immunoassay (LFIA) tests for estimating individual disease risk is unclear. The REACT-2 study in England, UK, obtained self-administered SARS-CoV-2 LFIA test results from 361,801 adults in January-May 2021. Here, we link to routine data on subsequent hospitalisation (to September 2021), and death (to December 2021). Among those who had received one or more vaccines, a negative LFIA is associated with increased risk of hospitalisation with COVID-19 (HR: 2.73 [95% confidence interval: 1.15,6.48]), death (all-cause) (HR: 1.59, 95% CI:1.07, 2.37), and death with COVID-19 as underlying cause (20.6 [1.83,232]). For people designated at high risk from COVID-19, who had received one or more vaccines, there is an additional risk of all-cause mortality of 1.9 per 1000 for those testing antibody negative compared to positive. However, the LFIA does not provide substantial predictive information over and above that which is available from detailed sociodemographic and health-related variables. Nonetheless, this simple test provides a marker which could be a valuable addition to understanding population and individual-level risk.
AU  - Whitaker,M
AU  - Davies,B
AU  - Atchison,C
AU  - Barclay,W
AU  - Ashby,D
AU  - Darzi,A
AU  - Riley,S
AU  - Cooke,G
AU  - Donnelly,C
AU  - Chadeau,M
AU  - Elliott,P
AU  - Ward,H
DO  - 10.1038/s41467-023-40643-w
PY  - 2023///
SN  - 2041-1723
TI  - SARS-CoV-2 rapid antibody test results and subsequent risk of hospitalisation and death in 361,801 people
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-023-40643-w
UR  - http://hdl.handle.net/10044/1/106083
VL  - 14
ER  -
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