Imperial College London
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Professor Christl Donnelly CBE FMedSci FRS

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

c.donnelly Website

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Griffee:2023:10.1016/j.rpth.2023.102142,
author = {Griffee, MJ and Bozza, PT and Reyes, LF and Eddington, DP and Rosenberger, D and Merson, L and Citarella, BW and Fanning, JP and Alexander, PMA and Fraser, J and Dalton, H and Cho, S-M and ISARIC, Clinical Characterisation Group},
doi = {10.1016/j.rpth.2023.102142},
journal = {Res Pract Thromb Haemost},
title = {Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry.},
url = {http://dx.doi.org/10.1016/j.rpth.2023.102142},
volume = {7},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: COVID-19 has been associated with a broad range of thromboembolic, ischemic, and hemorrhagic complications (coagulopathy complications). Most studies have focused on patients with severe disease from high-income countries (HICs). OBJECTIVES: The main aims were to compare the frequency of coagulopathy complications in developing countries (low- and middle-income countries [LMICs]) with those in HICs, delineate the frequency across a range of treatment levels, and determine associations with in-hospital mortality. METHODS: Adult patients enrolled in an observational, multinational registry, the International Severe Acute Respiratory and Emerging Infections COVID-19 study, between January 1, 2020, and September 15, 2021, met inclusion criteria, including admission to a hospital for laboratory-confirmed, acute COVID-19 and data on complications and survival. The advanced-treatment cohort received care, such as admission to the intensive care unit, mechanical ventilation, or inotropes or vasopressors; the basic-treatment cohort did not receive any of these interventions. RESULTS: The study population included 495,682 patients from 52 countries, with 63% from LMICs and 85% in the basic treatment cohort. The frequency of coagulopathy complications was higher in HICs (0.76%-3.4%) than in LMICs (0.09%-1.22%). Complications were more frequent in the advanced-treatment cohort than in the basic-treatment cohort. Coagulopathy complications were associated with increased in-hospital mortality (odds ratio, 1.58; 95% CI, 1.52-1.64). The increased mortality associated with these complications was higher in LMICs (58.5%) than in HICs (35.4%). After controlling for coagulopathy complications, treatment intensity, and multiple other factors, the mortality was higher among patients in LMICs than among patients in HICs (odds ratio, 1.45; 95% CI, 1.39-1.51). CONCLUSION: In a large, international registry of patients hospitalized for COVID-19, coagulopathy complications were mo
AU  - Griffee,MJ
AU  - Bozza,PT
AU  - Reyes,LF
AU  - Eddington,DP
AU  - Rosenberger,D
AU  - Merson,L
AU  - Citarella,BW
AU  - Fanning,JP
AU  - Alexander,PMA
AU  - Fraser,J
AU  - Dalton,H
AU  - Cho,S-M
AU  - ISARIC,Clinical Characterisation Group
DO  - 10.1016/j.rpth.2023.102142
PY  - 2023///
TI  - Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry.
T2  - Res Pract Thromb Haemost
UR  - http://dx.doi.org/10.1016/j.rpth.2023.102142
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37601011
VL  - 7
ER  -
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