Imperial College London
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Professor Christl Donnelly CBE FMedSci FRS

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

c.donnelly Website

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gonçalves:2023:10.1016/j.medj.2023.08.005,
author = {Gonçalves, BP and Jassat, W and Baruch, J and Hashmi, M and Rojek, A and Dasgupta, A and Martin-Loeches, I and Reyes, LF and Piubelli, C and Citarella, BW and Kartsonaki, C and Lefèvre, B and López, Revilla JW and Lunn, M and Harrison, EM and Kraemer, MUG and Shrapnel, S and Horby, P and Bisoffi, Z and Olliaro, PL and Merson, L and ISARIC, Clinical Characterisation Group},
doi = {10.1016/j.medj.2023.08.005},
journal = {Med},
pages = {797--812.e2},
title = {A multi-country analysis of COVID-19 hospitalizations by vaccination status.},
url = {http://dx.doi.org/10.1016/j.medj.2023.08.005},
volume = {4},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Individuals vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), when infected, can still develop disease that requires hospitalization. It remains unclear whether these patients differ from hospitalized unvaccinated patients with regard to presentation, coexisting comorbidities, and outcomes. METHODS: Here, we use data from an international consortium to study this question and assess whether differences between these groups are context specific. Data from 83,163 hospitalized COVID-19 patients (34,843 vaccinated, 48,320 unvaccinated) from 38 countries were analyzed. FINDINGS: While typical symptoms were more often reported in unvaccinated patients, comorbidities, including some associated with worse prognosis in previous studies, were more common in vaccinated patients. Considerable between-country variation in both in-hospital fatality risk and vaccinated-versus-unvaccinated difference in this outcome was observed. CONCLUSIONS: These findings will inform allocation of healthcare resources in future surges as well as design of longer-term international studies to characterize changes in clinical profile of hospitalized COVID-19 patients related to vaccination history. FUNDING: This work was made possible by the UK Foreign, Commonwealth and Development Office and Wellcome (215091/Z/18/Z, 222410/Z/21/Z, 225288/Z/22/Z, and 220757/Z/20/Z); the Bill & Melinda Gates Foundation (OPP1209135); and the philanthropic support of the donors to the University of Oxford's COVID-19 Research Response Fund (0009109). Additional funders are listed in the "acknowledgments" section.
AU  - Gonçalves,BP
AU  - Jassat,W
AU  - Baruch,J
AU  - Hashmi,M
AU  - Rojek,A
AU  - Dasgupta,A
AU  - Martin-Loeches,I
AU  - Reyes,LF
AU  - Piubelli,C
AU  - Citarella,BW
AU  - Kartsonaki,C
AU  - Lefèvre,B
AU  - López,Revilla JW
AU  - Lunn,M
AU  - Harrison,EM
AU  - Kraemer,MUG
AU  - Shrapnel,S
AU  - Horby,P
AU  - Bisoffi,Z
AU  - Olliaro,PL
AU  - Merson,L
AU  - ISARIC,Clinical Characterisation Group
DO  - 10.1016/j.medj.2023.08.005
EP  - 812
PY  - 2023///
SP  - 797
TI  - A multi-country analysis of COVID-19 hospitalizations by vaccination status.
T2  - Med
UR  - http://dx.doi.org/10.1016/j.medj.2023.08.005
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37738979
VL  - 4
ER  -
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