Imperial College London
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Professor Christl Donnelly CBE FMedSci FRS

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

c.donnelly Website

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hampshire:2024:10.1056/NEJMoa2311330,
author = {Hampshire, A and Azor, A and Atchison, C and Trender, W and Hellyer, PJ and Giunchiglia, V and Husain, M and Cooke, GS and Cooper, E and Lound, A and Donnelly, CA and Chadeau-Hyam, M and Ward, H and Elliott, P},
doi = {10.1056/NEJMoa2311330},
journal = {New England Journal of Medicine},
pages = {806--818},
title = {Cognition and memory after Covid-19 in a large community sample},
url = {http://dx.doi.org/10.1056/NEJMoa2311330},
volume = {390},
year = {2024}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Cognitive symptoms after coronavirus disease 2019 (Covid-19), the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are well-recognized. Whether objectively measurable cognitive deficits exist and how long they persist are unclear. METHODS: We invited 800,000 adults in a study in England to complete an online assessment of cognitive function. We estimated a global cognitive score across eight tasks. We hypothesized that participants with persistent symptoms (lasting ≥12 weeks) after infection onset would have objectively measurable global cognitive deficits and that impairments in executive functioning and memory would be observed in such participants, especially in those who reported recent poor memory or difficulty thinking or concentrating ("brain fog"). RESULTS: Of the 141,583 participants who started the online cognitive assessment, 112,964 completed it. In a multiple regression analysis, participants who had recovered from Covid-19 in whom symptoms had resolved in less than 4 weeks or at least 12 weeks had similar small deficits in global cognition as compared with those in the no-Covid-19 group, who had not been infected with SARS-CoV-2 or had unconfirmed infection (-0.23 SD [95% confidence interval {CI}, -0.33 to -0.13] and -0.24 SD [95% CI, -0.36 to -0.12], respectively); larger deficits as compared with the no-Covid-19 group were seen in participants with unresolved persistent symptoms (-0.42 SD; 95% CI, -0.53 to -0.31). Larger deficits were seen in participants who had SARS-CoV-2 infection during periods in which the original virus or the B.1.1.7 variant was predominant than in those infected with later variants (e.g., -0.17 SD for the B.1.1.7 variant vs. the B.1.1.529 variant; 95% CI, -0.20 to -0.13) and in participants who had been hospitalized than in those who had not been hospitalized (e.g., intensive care unit admission, -0.35 SD; 95% CI, -0.49 to -0.20). Results of the analyses were similar to
AU  - Hampshire,A
AU  - Azor,A
AU  - Atchison,C
AU  - Trender,W
AU  - Hellyer,PJ
AU  - Giunchiglia,V
AU  - Husain,M
AU  - Cooke,GS
AU  - Cooper,E
AU  - Lound,A
AU  - Donnelly,CA
AU  - Chadeau-Hyam,M
AU  - Ward,H
AU  - Elliott,P
DO  - 10.1056/NEJMoa2311330
EP  - 818
PY  - 2024///
SN  - 0028-4793
SP  - 806
TI  - Cognition and memory after Covid-19 in a large community sample
T2  - New England Journal of Medicine
UR  - http://dx.doi.org/10.1056/NEJMoa2311330
UR  - https://www.ncbi.nlm.nih.gov/pubmed/38416429
UR  - https://www.nejm.org/doi/10.1056/NEJMoa2311330
UR  - http://hdl.handle.net/10044/1/110909
VL  - 390
ER  -
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