Imperial College London
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ProfessorFrankKelly

Faculty of Medicine, School of Public Health

Battcock Chair in Community Health and Policy
 
 
 
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Contact

 

+44 (0)20 7594 8098 ext 48098frank.kelly Website

 
 
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Location

 

Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Tandon:2023:10.1016/j.cpcardiol.2022.101460,
author = {Tandon, S and Grande, AJ and Karamanos, A and Cruickshank, JK and Roever, L and Mudway, IS and Kelly, FJ and Ayis, S and Harding, S},
doi = {10.1016/j.cpcardiol.2022.101460},
journal = {Current Problems in Cardiology},
title = {Association of ambient air pollution with blood pressure in adolescence: a systematic-review and meta-analysis},
url = {http://dx.doi.org/10.1016/j.cpcardiol.2022.101460},
volume = {48},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We systematically reviewed the association of ambient air pollution with blood pressure (BP) as a primary outcome in adolescents (10-19 years). Five databases (Ovid Medline, Ovid Embase, Web of Science, The Cochrane Library, and LILACS) were searched for relevant articles published up to August 2022. Meta-analyses were conducted using STATA v17 (Protocol - OSF Registries https://doi.org/10.17605/OSF.IO/96G5Q). Eight studies (5 cohort, 3 cross-sectional) with approximately 15,000 adolescents were included. Data from 6 studies were suitable for inclusion in the meta-analyses. In sub-group analyses, non-significant positive associations were observed for cohort studies assessing long-term exposure to PM10, PM2.5, and NO2 on systolic and diastolic BP. At age 12 years old (3702 adolescents), we found significant positive associations for long-term exposure to PM2.5(β=5.33 (1.56, 9.09) mmHg) and PM10 (β=2.47 (0.10, 4.85) mmHg) on diastolic BP. Significant positive associations were observed (3,592 adolescents) for long-term exposure to PM10(β=0.34 (0.19, 0.50) mmHg) and NO2 on diastolic BP (β=0.40 (0.09, 0.71) mmHg), and PM10 on systolic BP (β=0.48 (0.19, 0.77) mmHg). The overall quality of evidence analysed was graded as “low/very low.” Insufficient data for short-term exposures to PM2.5, PM10, NO2, CO on BP led to their exclusion from the meta-analysis. Inconsistent associations were reported for gender-stratified results. The evidence, though of low-quality and limited, indicated that ambient air pollution was positively associated with adolescent BP. Future studies need improved measures of air pollutant exposures, consideration of gender and socio-economic circumstances on the observed pollution effects, as well as adjustment for other potential confounding factors.
AU  - Tandon,S
AU  - Grande,AJ
AU  - Karamanos,A
AU  - Cruickshank,JK
AU  - Roever,L
AU  - Mudway,IS
AU  - Kelly,FJ
AU  - Ayis,S
AU  - Harding,S
DO  - 10.1016/j.cpcardiol.2022.101460
PY  - 2023///
SN  - 0146-2806
TI  - Association of ambient air pollution with blood pressure in adolescence: a systematic-review and meta-analysis
T2  - Current Problems in Cardiology
UR  - http://dx.doi.org/10.1016/j.cpcardiol.2022.101460
UR  - https://www.sciencedirect.com/science/article/pii/S0146280622003577
VL  - 48
ER  -
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