Imperial College London
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ProfessorFrankKelly

Faculty of Medicine, School of Public Health

Battcock Chair in Community Health and Policy
 
 
 
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Contact

 

+44 (0)20 7594 8098 ext 48098frank.kelly Website

 
 
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Location

 

Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Han:2024:10.1016/j.envres.2024.118354,
author = {Han, W and Zhang, J and Xu, Z and Yang, T and Huang, J and Beevers, S and Kelly, F and Li, G},
doi = {10.1016/j.envres.2024.118354},
journal = {Environmental Research},
title = {Could the association between ozone and arterial stiffness be modified by fish oil supplementation?},
url = {http://dx.doi.org/10.1016/j.envres.2024.118354},
volume = {249},
year = {2024}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Arterial stiffness (AS) is an important predicting factor for cardiovascular disease. However, no epidemiological studies have ever explored the mediating role of biomarkers in the association between ozone and AS, nor weather fish oil modified such association. METHODS: Study participants were drawn from the UK biobank, and a total of 95,699 middle-aged and older adults were included in this study. Ozone was obtained from Community Multiscale Air Quality (CMAQ) model matched to residential addresses, fish oil from self-reported intake, and arterial stiffness was based on device measurements. First, we applied a double robust approach to explore the association between ozone or fish oil intake and arterial stiffness, adjusting for potential confounders at the individual and regional levels. Then, how triglycerides, apolipoprotein B (Apo B)/apolipoprotein A (ApoA) and non-high-density lipoprotein cholesterol (Non-HDL-C) mediate the relationship between ozone and AS. Last, the modifying role of fish oil was further explored by stratified analysis. RESULTS: The mean age of participants was 55 years; annual average ozone exposure was associated with ASI (beta:0.189 [95%CI: 0.146 to 0.233], P < 0.001), and compared to participants who did not consume fish oil, fish oil users had a lower ASI (beta: 0.061 [95%CI: -0.111 to -0.010], P = 0.016). The relationship between ozone exposure and AS was mediated by triglycerides, ApoB/ApoA, and Non-HDL-C with mediation proportions ranging from 10.90% to 18.30%. Stratified analysis showed lower estimates on the ozone-AS relationship in fish oil users (P = 0.011). CONCLUSION: Ozone exposure was associated with higher levels of arterial stiffness, in contrast to fish oil consumption, which showed a protective association. The association between ozone exposure and arterial stiffness was partially mediated by some biomarkers. In the general population, fish oil consumption might provide prote
AU  - Han,W
AU  - Zhang,J
AU  - Xu,Z
AU  - Yang,T
AU  - Huang,J
AU  - Beevers,S
AU  - Kelly,F
AU  - Li,G
DO  - 10.1016/j.envres.2024.118354
PY  - 2024///
SN  - 0013-9351
TI  - Could the association between ozone and arterial stiffness be modified by fish oil supplementation?
T2  - Environmental Research
UR  - http://dx.doi.org/10.1016/j.envres.2024.118354
UR  - https://www.ncbi.nlm.nih.gov/pubmed/38325778
UR  - https://www.sciencedirect.com/science/article/pii/S0013935124002585
UR  - http://hdl.handle.net/10044/1/109863
VL  - 249
ER  -
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