Imperial College London
Alternate

Professor Robin Carhart-Harris

Faculty of Medicine, Department of Brain Sciences

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 7992r.carhart-harris

 
 
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Assistant

 

Miss Bruna Cunha +44 (0)20 7594 7992

 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Vohryzek:2024:braincomms/fcae049,
author = {Vohryzek, J and Cabral, J and Lord, L-D and Fernandes, HM and Roseman, L and Nutt, DJ and Carhart-Harris, RL and Deco, G and Kringelbach, ML},
doi = {braincomms/fcae049},
journal = {Brain Commun},
title = {Brain dynamics predictive of response to psilocybin for treatment-resistant depression.},
url = {http://dx.doi.org/10.1093/braincomms/fcae049},
volume = {6},
year = {2024}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Psilocybin therapy for depression has started to show promise, yet the underlying causal mechanisms are not currently known. Here, we leveraged the differential outcome in responders and non-responders to psilocybin (10 and 25mg, 7 days apart) therapy for depression-to gain new insights into regions and networks implicated in the restoration of healthy brain dynamics. We used large-scale brain modelling to fit the spatiotemporal brain dynamics at rest in both responders and non-responders before treatment. Dynamic sensitivity analysis of systematic perturbation of these models enabled us to identify specific brain regions implicated in a transition from a depressive brain state to a healthy one. Binarizing the sample into treatment responders (>50% reduction in depressive symptoms) versus non-responders enabled us to identify a subset of regions implicated in this change. Interestingly, these regions correlate with in vivo density maps of serotonin receptors 5-hydroxytryptamine 2a and 5-hydroxytryptamine 1a, which psilocin, the active metabolite of psilocybin, has an appreciable affinity for, and where it acts as a full-to-partial agonist. Serotonergic transmission has long been associated with depression, and our findings provide causal mechanistic evidence for the role of brain regions in the recovery from depression via psilocybin.
AU  - Vohryzek,J
AU  - Cabral,J
AU  - Lord,L-D
AU  - Fernandes,HM
AU  - Roseman,L
AU  - Nutt,DJ
AU  - Carhart-Harris,RL
AU  - Deco,G
AU  - Kringelbach,ML
DO  - braincomms/fcae049
PY  - 2024///
TI  - Brain dynamics predictive of response to psilocybin for treatment-resistant depression.
T2  - Brain Commun
UR  - http://dx.doi.org/10.1093/braincomms/fcae049
UR  - https://www.ncbi.nlm.nih.gov/pubmed/38515439
VL  - 6
ER  -
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