Publications
229 results found
Takáts Z, Schlosser G, Vékey K, 2003, Hydrogen/deuterium exchange of electrosprayed ions in the atmospheric interface of a commercial triple-quadrupole mass spectrometer, Symposium in Honor of Helmut Schwaz, Publisher: ELSEVIER SCIENCE BV, Pages: 729-741, ISSN: 1387-3806
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- Citations: 20
Schlosser G, Takáts Z, Vékey K, et al., 2003, Mass spectrometric analysis of combinatorial peptide libraries derived from the tandem repeat unit of MUC2 mucin, JOURNAL OF PEPTIDE SCIENCE, Vol: 9, Pages: 361-374, ISSN: 1075-2617
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- Citations: 3
Takats Z, Nanita SC, Cooks RG, et al., 2003, Amino acid clusters formed by sonic spray ionization, ANALYTICAL CHEMISTRY, Vol: 75, Pages: 1514-1523, ISSN: 0003-2700
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- Citations: 133
Trézl L, Hullán L, Jászay ZM, et al., 2003, Antagonistic reactions of arginine and lysine against formaldehyde and their relation to cell proliferation, apoptosis, folate cycle and photosynthesis, MOLECULAR AND CELLULAR BIOCHEMISTRY, Vol: 244, Pages: 167-176, ISSN: 0300-8177
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- Citations: 24
Trézl L, Hullán L, Jászay ZM, et al., 2003, Antagonistic reactions of arginine and lysine against formaldehyde and their relation to cell proliferation, apoptosis, folate cycle and photosynthesis., Mol Cell Biochem, Vol: 244, Pages: 167-176, ISSN: 0300-8177
1H, 13C NMR, ESMS and MS/MS investigations proved that there is an antagonism in the spontaneous reaction of formaldehyde with L-lysine and L-arginine. L-Arginine can only be hydroxymethylated on the guanidino group in a very fast reaction forming mono-, di-, and trihydroxymethyl arginines (HMA). L-Lysine can be methylated on the epsilon-amino group forming mono-, di-, and trimethyl lysine on physiological pH. Hydroxymethyl arginines are relative stable, isolable products, and can also be formed in biological systems, especially in plants. Significant amounts of hydroxymethyl arginines were identified in the aqueous extract of lyophilized kohlrabi, which can be formed in photosynthesis during CO2 fixation. 14C-Formaldehyde formed in a short-term (10, 30 sec) 14CO2 fixation reaction in Zea mays L. (early maturity variety: Szegedi TC 277) was captured by L-arginine, which occurs in leaves in large amount. Formaldehyde formed during photosynthesis can react not only with the arginine, but with ribulose-1,5-diphosphate present in leaves. In model reactions formaldehyde can react with the 'ene diole' group of ribulose-1,5-diphosphate in the absence of Rubisco enzyme, which is a similar reaction to the addition of formaldehyde to L-ascorbic acid. Hydroxymethyl arginines (HMA) are endogenous formaldehyde carrier molecules transferring the bound formaldehyde to thymidylate synthase enzyme system incorporating it into the folate cycle. HMA can also carry the bound formaldehyde to the cells especially to the tumorous cells (HT29 adenocarcinoma), and cause significant inhibition of cell proliferation and causes apoptosis.
Takats Z, Nanita SC, Cooks RG, 2003, Serine octamer reactions: Indicators of prebiotic relevance, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 42, Pages: 3521-3523, ISSN: 1433-7851
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- Citations: 106
Nagy K, Takáts Z, Pollreisz F, et al., 2003, Direct tandem mass spectrometric analysis of amino acids in dried blood spots without chemical derivatization for neonatal screening, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, Vol: 17, Pages: 983-990, ISSN: 0951-4198
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- Citations: 52
Takáts Z, Drahos L, Schlosser G, et al., 2002, Feasibility of formation of hot ions in electrospray, ANALYTICAL CHEMISTRY, Vol: 74, Pages: 6427-6429, ISSN: 0003-2700
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- Citations: 23
Koch KJ, Gozzo FC, Nanita SC, et al., 2002, Chiral transmission between amino acids: Chirally selective amino acid substitution in the serine octamer as a possible step in homochirogenesis, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 41, Pages: 1721-+, ISSN: 1433-7851
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- Citations: 117
Takats Z, Koch KJ, Cooks RG, 2001, Organic chloramine analysis and free chlorine quantification by electrospray and atmospheric pressure chemical ionization tandem mass spectrometry, ANALYTICAL CHEMISTRY, Vol: 73, Pages: 4522-4529, ISSN: 0003-2700
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- Citations: 30
Cooks RG, Riter LS, Koch KJ, et al., 2001, Miniature mass spectrometers with membrane interfaces for on-site., ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol: 221, Pages: U462-U462, ISSN: 0065-7727
Riter LS, Takáts Z, Charles L, et al., 2001, High surface area membrane introduction mass spectrometry for analysis of volatile and semi-volatile organic compounds in air, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, Vol: 15, Pages: 1520-1524, ISSN: 0951-4198
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- Citations: 27
Riter LS, Takáts Z, Cooks RG, 2001, Single-sided membrane introduction mass spectrometry for on-line determination of semi-volatile organic compounds in air, ANALYST, Vol: 126, Pages: 1980-1984, ISSN: 0003-2654
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- Citations: 40
Takáts Z, Vargha M, Vékey K, 2001, Investigation of atrazine metabolism in river sediment by high-performance liquid chromatography/mass spectrometry, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, Vol: 15, Pages: 1735-1742, ISSN: 0951-4198
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- Citations: 14
Takáts Z, Vékey K, Hegedüs L, 2001, Qualitative and quantitative determination of poloxamer surfactants by mass spectrometry, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, Vol: 15, Pages: 805-810, ISSN: 0951-4198
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- Citations: 22
Kádár M, Takáts Z, Karancsi T, et al., 1999, The role of halogen substituents in the electrooxidation of 4-halogenoanilines in neutral acetonitrile, International Symposium on Electrochemical and Biosensors (Matrafured 98), Publisher: WILEY-BLACKWELL, Pages: 809-813, ISSN: 1040-0397
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- Citations: 13
Takáts Z, Torkos K, 1998, Determination of chlorobenzenes in environmental samples using solid phase microextraction, thermal desorption and analysis by gas chromatography coupled to FID, ECD, MSD IRD detectors, Balaton Symposium 97 on High-Performance Separation Methods, Publisher: VIEWEG, Pages: 74-80, ISSN: 0009-5893
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- Citations: 12
Takáts Z, Vékey K, 1998, Electrospray and atmospheric pressure chemical ionisation of aromatic compounds in dichloromethane solvent, EUROPEAN MASS SPECTROMETRY, Vol: 4, Pages: 365-370, ISSN: 1356-1049
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- Citations: 3
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