@article{Tann:2017:cid/cix662,
author = {Tann, CJ and Martinello, KA and Sadoo, S and Lawn, JE and Seale, AC and Vega-Poblete, A and Russell, NJ and Baker, CJ and Bartlett, L and Cutland, C and Gravett, MG and Ip, M and Le, Doare K and Madhi, SA and Rubens, CE and Saha, SK and Schrag, S and Sobanjo-ter, Meulen A and Vekemans, J and Heath, PT and GBS, Neonatal Encephalopathy Investigator Group},
doi = {cid/cix662},
journal = {Clinical Infectious Diseases},
pages = {S173--S189},
title = {Neonatal Encephalopathy With Group B Streptococcal Disease Worldwide: Systematic Review, Investigator Group Datasets, and Meta-analysis},
url = {http://dx.doi.org/10.1093/cid/cix662},
volume = {65},
year = {2017}
}

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TY  - JOUR
AB  - BackgroundNeonatal encephalopathy (NE) is a leading cause of child mortality and longer-term impairment. Infection can sensitize the newborn brain to injury; however, the role of group B streptococcal (GBS) disease has not been reviewed. This paper is the ninth in an 11-article series estimating the burden of GBS disease; here we aim to assess the proportion of GBS in NE cases.MethodsWe conducted systematic literature reviews (PubMed/Medline, Embase, Latin American and Caribbean Health Sciences Literature [LILACS], World Health Organization Library Information System [WHOLIS], and Scopus) and sought unpublished data from investigator groups reporting GBS-associated NE. Meta-analyses estimated the proportion of GBS disease in NE and mortality risk. UK population-level data estimated the incidence of GBS-associated NE.ResultsFour published and 25 unpublished datasets were identified from 13 countries (N = 10436). The proportion of NE associated with GBS was 0.58% (95% confidence interval [CI], 0.18%–.98%). Mortality was significantly increased in GBS-associated NE vs NE alone (risk ratio, 2.07 [95% CI, 1.47–2.91]). This equates to a UK incidence of GBS-associated NE of 0.019 per 1000 live births.ConclusionsThe consistent increased proportion of GBS disease in NE and significant increased risk of mortality provides evidence that GBS infection contributes to NE. Increased information regarding this and other organisms is important to inform interventions, especially in low- and middle-resource contexts.
AU  - Tann,CJ
AU  - Martinello,KA
AU  - Sadoo,S
AU  - Lawn,JE
AU  - Seale,AC
AU  - Vega-Poblete,A
AU  - Russell,NJ
AU  - Baker,CJ
AU  - Bartlett,L
AU  - Cutland,C
AU  - Gravett,MG
AU  - Ip,M
AU  - Le,Doare K
AU  - Madhi,SA
AU  - Rubens,CE
AU  - Saha,SK
AU  - Schrag,S
AU  - Sobanjo-ter,Meulen A
AU  - Vekemans,J
AU  - Heath,PT
AU  - GBS,Neonatal Encephalopathy Investigator Group
DO  - cid/cix662
EP  - 189
PY  - 2017///
SN  - 1058-4838
SP  - 173
TI  - Neonatal Encephalopathy With Group B Streptococcal Disease Worldwide: Systematic Review, Investigator Group Datasets, and Meta-analysis
T2  - Clinical Infectious Diseases
UR  - http://dx.doi.org/10.1093/cid/cix662
UR  - http://hdl.handle.net/10044/1/53189
VL  - 65
ER  - 

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