See a list of publications below or visit the Photonics academic staff page and click on a particular member of staff to access their personal web page, which includes a list of their own publications.
@inproceedings{Battle:2023:CLEO/EUROPE-EQEC57999.2023.10232450,
author = {Battle, RA and Simon, D and Xiang, Y and Robinson, K and Runcorn, TH and Murray, RT and Takats, Z},
doi = {CLEO/EUROPE-EQEC57999.2023.10232450},
title = {Cellular Level Resolution Ambient Mass Spectrometry Imaging using 3 µm Laser Ablation},
url = {http://dx.doi.org/10.1109/CLEO/EUROPE-EQEC57999.2023.10232450},
year = {2023}
}
TY - CPAPER
AB - Tissue can be rapidly ablated by lasers with wavelength around λ = 3 µm, which is strongly absorbed by water [1]. Mass spectrometry (MS) analysis of the ablated material can subsequently provide rich chemical data about the molecular content of the tissue. In mass spectrometry imaging (MSI), spatially resolved molecular data is obtained from a sample by collecting multiple mass spectra. From these individual spectra, the spatial distribution of molecules of interest can be mapped. In this work, we report a single-cell level resolution mass spectrometry imaging platform based on laser ablation using a parametric 3 µm laser source and Rapid Evaporative Ionization Mass Spectrometry (REIMS) [2]. The laser source is specifically developed to have high beam quality and sub-ns duration. This has allowed us to overcome previous ambient MSI spatial resolution limits, a key step to translating the benefits of MS analysis to clinical applications.
AU - Battle,RA
AU - Simon,D
AU - Xiang,Y
AU - Robinson,K
AU - Runcorn,TH
AU - Murray,RT
AU - Takats,Z
DO - CLEO/EUROPE-EQEC57999.2023.10232450
PY - 2023///
TI - Cellular Level Resolution Ambient Mass Spectrometry Imaging using 3 µm Laser Ablation
UR - http://dx.doi.org/10.1109/CLEO/EUROPE-EQEC57999.2023.10232450
ER -