BibTex format
@article{Tan:2024:10.1109/tbme.2024.3426487,
author = {Tan, Q and Riemer, K and Hansen-Shearer, J and Yan, J and Toulemonde, M and Taylor, L and Yan, S and Dunsby, C and Weinberg, PD and Tang, M-X},
doi = {10.1109/tbme.2024.3426487},
journal = {IEEE Transactions on Biomedical Engineering},
title = {Transcutaneous imaging of rabbit kidney using 3-D acoustic wave sparsely activated localization microscopy with a row-column-addressed array},
url = {http://dx.doi.org/10.1109/tbme.2024.3426487},
year = {2024}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Objective: Super-resolution ultrasound (SRUS) imaging through localizing and tracking microbubbles, also known as ultrasound localization microscopy (ULM), can produce sub-diffraction resolution images of micro-vessels. We have recently demonstrated 3-D selective SRUS with a matrix array and phase change contrast agents (PCCAs). However, this method is limited to a small field of view (FOV) and by the complex hardware required. Method: This study proposed 3-D acoustic wave sparsely activated localization microscopy (AWSALM) using PCCAs and a 128+128 row-column-addressed (RCA) array, which offers ultrafast acquisition with over 6 times larger FOV and 4 times reduction in hardware complexity than a 1024-element matrix array. We first validated this method on an in-vitro microflow phantom and subsequently demonstrated non-invasively on a rabbit kidney in-vivo. Results: Our results show that 3-D AWSALM images of the phantom covering a 25×25×40 mm 3 volume can be generated under 5 seconds with an 8 times resolution improvement over the system point spread function. The full volume of the rabbit kidney can be covered to generate 3-D microvascular structure, flow speed and direction super-resolution maps under 15 seconds, combining the large FOV of RCA with the high resolution of SRUS. Additionally, 3-D AWSALM is selective and can visualize the microvasculature within the activation volume and downstream vessels in isolation. Sub-sets of the kidney microvasculature can be imaged through selective activation of PCCAs. Conclusion: Our study demonstrates large FOV 3-D AWSALM using an RCA probe. Significance: 3-D AWSALM offers an unique in-vivo imaging tool for fast, selective and large FOV vascular flow mapping.
AU - Tan,Q
AU - Riemer,K
AU - Hansen-Shearer,J
AU - Yan,J
AU - Toulemonde,M
AU - Taylor,L
AU - Yan,S
AU - Dunsby,C
AU - Weinberg,PD
AU - Tang,M-X
DO - 10.1109/tbme.2024.3426487
PY - 2024///
SN - 0018-9294
TI - Transcutaneous imaging of rabbit kidney using 3-D acoustic wave sparsely activated localization microscopy with a row-column-addressed array
T2 - IEEE Transactions on Biomedical Engineering
UR - http://dx.doi.org/10.1109/tbme.2024.3426487
UR - http://hdl.handle.net/10044/1/113438
ER -