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@article{Gorlitz:2017:10.3390/photonics4030040,
author = {Gorlitz, F and Corcoran, DS and Garcia, Castano EA and Leitinger, B and Neil, MAA and Dunsby, CW and French, PMW},
doi = {10.3390/photonics4030040},
journal = {Photonics},
title = {Mapping molecular function to biological nanostructure: combining structured illumination microscopy with fluorescence lifetime imaging (SIM+FLIM)},
url = {http://dx.doi.org/10.3390/photonics4030040},
volume = {4},
year = {2017}
}
TY - JOUR
AB - We present a new microscope integrating super-resolved imaging using structured illumination microscopy (SIM) with wide-field optically sectioned fluorescence lifetime imaging (FLIM) to provide optical mapping of molecular function and its correlation with biological nanostructure below the conventional diffraction limit. We illustrate this SIM + FLIM capability to map FRET readouts applied to the aggregation of discoidin domain receptor 1 (DDR1) in Cos 7 cells following ligand stimulation and to the compaction of DNA during the cell cycle.
AU - Gorlitz,F
AU - Corcoran,DS
AU - Garcia,Castano EA
AU - Leitinger,B
AU - Neil,MAA
AU - Dunsby,CW
AU - French,PMW
DO - 10.3390/photonics4030040
PY - 2017///
SN - 2304-6732
TI - Mapping molecular function to biological nanostructure: combining structured illumination microscopy with fluorescence lifetime imaging (SIM+FLIM)
T2 - Photonics
UR - http://dx.doi.org/10.3390/photonics4030040
UR - http://hdl.handle.net/10044/1/49839
VL - 4
ER -