@article{Siegel:2024:10.1038/s41586-024-07624-5,
author = {Siegel, JS and Subramanian, S and Perry, D and Kay, BP and Gordon, EM and Laumann, TO and Reneau, TR and Metcalf, NV and Chacko, RV and Gratton, C and Horan, C and Krimmel, SR and Shimony, JS and Schweiger, JA and Wong, DF and Bender, DA and Scheidter, KM and Whiting, FI and Padawer-Curry, JA and Shinohara, RT and Chen, Y and Moser, J and Yacoub, E and Nelson, SM and Vizioli, L and Fair, DA and Lenze, EJ and Carhart-Harris, R and Raison, CL and Raichle, ME and Snyder, AZ and Nicol, GE and Dosenbach, NUF},
doi = {10.1038/s41586-024-07624-5},
journal = {Nature},
pages = {131--138},
title = {Psilocybin desynchronizes the human brain.},
url = {http://dx.doi.org/10.1038/s41586-024-07624-5},
volume = {632},
year = {2024}
}

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TY  - JOUR
AB  - A single dose of psilocybin, a psychedelic that acutely causes distortions of space-time perception and ego dissolution, produces rapid and persistent therapeutic effects in human clinical trials1-4. In animal models, psilocybin induces neuroplasticity in cortex and hippocampus5-8. It remains unclear how human brain network changes relate to subjective and lasting effects of psychedelics. Here we tracked individual-specific brain changes with longitudinal precision functional mapping (roughly 18 magnetic resonance imaging visits per participant). Healthy adults were tracked before, during and for 3 weeks after high-dose psilocybin (25 mg) and methylphenidate (40 mg), and brought back for an additional psilocybin dose 6-12 months later. Psilocybin massively disrupted functional connectivity (FC) in cortex and subcortex, acutely causing more than threefold greater change than methylphenidate. These FC changes were driven by brain desynchronization across spatial scales (areal, global), which dissolved network distinctions by reducing correlations within and anticorrelations between networks. Psilocybin-driven FC changes were strongest in the default mode network, which is connected to the anterior hippocampus and is thought to create our sense of space, time and self. Individual differences in FC changes were strongly linked to the subjective psychedelic experience. Performing a perceptual task reduced psilocybin-driven FC changes. Psilocybin caused persistent decrease in FC between the anterior hippocampus and default mode network, lasting for weeks. Persistent reduction of hippocampal-default mode network connectivity may represent a neuroanatomical and mechanistic correlate of the proplasticity and therapeutic effects of psychedelics.
AU  - Siegel,JS
AU  - Subramanian,S
AU  - Perry,D
AU  - Kay,BP
AU  - Gordon,EM
AU  - Laumann,TO
AU  - Reneau,TR
AU  - Metcalf,NV
AU  - Chacko,RV
AU  - Gratton,C
AU  - Horan,C
AU  - Krimmel,SR
AU  - Shimony,JS
AU  - Schweiger,JA
AU  - Wong,DF
AU  - Bender,DA
AU  - Scheidter,KM
AU  - Whiting,FI
AU  - Padawer-Curry,JA
AU  - Shinohara,RT
AU  - Chen,Y
AU  - Moser,J
AU  - Yacoub,E
AU  - Nelson,SM
AU  - Vizioli,L
AU  - Fair,DA
AU  - Lenze,EJ
AU  - Carhart-Harris,R
AU  - Raison,CL
AU  - Raichle,ME
AU  - Snyder,AZ
AU  - Nicol,GE
AU  - Dosenbach,NUF
DO  - 10.1038/s41586-024-07624-5
EP  - 138
PY  - 2024///
SP  - 131
TI  - Psilocybin desynchronizes the human brain.
T2  - Nature
UR  - http://dx.doi.org/10.1038/s41586-024-07624-5
UR  - https://www.ncbi.nlm.nih.gov/pubmed/39020167
VL  - 632
ER  - 

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