@article{Whittaker:2021:10.1136/bmj-2021-065834,
author = {Whittaker, H and Gulea, C and Koteci, A and Kallis, C and Morgan, A and Iwundu, C and Weeks, M and Gupta, R and Quint, J},
doi = {10.1136/bmj-2021-065834},
journal = {BMJ: British Medical Journal},
pages = {1--13},
title = {GP consultation rates for post-acute COVID-19 sequelae in cases managed in the community or hospital in the UK: a population-based study},
url = {http://dx.doi.org/10.1136/bmj-2021-065834},
volume = {375},
year = {2021}
}

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TY  - JOUR
AB  - ObjectiveTo describe GP consultation rates for post-COVID-19 sequelae in non-hospitalised and hospitalised COVID-19 patients, and among non-hospitalised individuals describe how GP consultation rates for post-COVID-19 sequelae change over time, as well as following COVID-19 vaccination. DesignPopulation-based cohort study.Setting1,392 general practices in England contributing to the Clinical Practice Research Datalink Aurum database.Participants456,002 COVID-19 cases diagnosed between 1st August 2020 to 14th February2021 (44.7% male; median age 61 years), either hospitalised within two weeks of diagnosis or not hospitalised and followed-up for a maximum of 9.2 months. A negative control group of individuals without COVID-19 (N=38,511) and patients with influenza before the pandemic (N=21,803) were used to contextualise findings.Main outcome measuresComparison of GP consultation rates for new symptoms, diseases, prescriptions and healthcare utilisation (HCU) in hospitalised and non-hospitalised individuals separately pre and post-COVID-19 infection using Cox regression and negative binomial regression for HCU. This was repeated for the negative control and influenza cohorts. In non-hospitalised individuals, outcomes were additionally described over time following COVID-19 diagnosis and compared pre and post-COVID-19 vaccine in individuals who were symptomatic post-COVID-19, using negative binomial regression. Results Relative to the negative control and influenza cohorts non-hospitalised patients (N=437,943) had  significantly higher GP consultation rates for multiple sequelae, the most common being loss of smell/taste (HRadj 5.28 [95%CI 3.89 to 7.17]; p<0.001), venous thromboembolism (VTE) (3.35 [2.87 to 3.90]; p<0.001), lung fibrosis (2.41 [1.37 to 4.25]; p=0.002), and muscle pain (1.89 [1.6 3to 2.20]; p<0.001), as well as HCU post COVID-19 diagnosis compared with 1-year prior. In terms of absolute proportions, the most common outcomes ≥ 4-weeks post-CO
AU  - Whittaker,H
AU  - Gulea,C
AU  - Koteci,A
AU  - Kallis,C
AU  - Morgan,A
AU  - Iwundu,C
AU  - Weeks,M
AU  - Gupta,R
AU  - Quint,J
DO  - 10.1136/bmj-2021-065834
EP  - 13
PY  - 2021///
SN  - 0959-535X
SP  - 1
TI  - GP consultation rates for post-acute COVID-19 sequelae in cases managed in the community or hospital in the UK: a population-based study
T2  - BMJ: British Medical Journal
UR  - http://dx.doi.org/10.1136/bmj-2021-065834
UR  - https://www.bmj.com/content/375/bmj-2021-065834
UR  - http://hdl.handle.net/10044/1/92750
VL  - 375
ER  - 

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