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Journal articleMassey LA, Micallef C, Paviour DC, et al., 2012,
Conventional Magnetic Resonance Imaging in Confirmed Progressive Supranuclear Palsy and Multiple System Atrophy
, MOVEMENT DISORDERS, Vol: 27, Pages: 1755-1762, ISSN: 0885-3185- Author Web Link
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- Citations: 133
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Journal articleWindsor RE, Strauss SJ, Kallis C, et al., 2012,
Germline Genetic Polymorphisms May Influence Chemotherapy Response and Disease Outcome in Osteosarcoma
, CANCER, Vol: 118, Pages: 1856-1867, ISSN: 0008-543X- Author Web Link
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- Citations: 105
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Journal articleGregoire SM, Smith K, Jaeger HR, et al., 2012,
Cerebral Microbleeds and Long-Term Cognitive Outcome: Longitudinal Cohort Study of Stroke Clinic Patients
, CEREBROVASCULAR DISEASES, Vol: 33, Pages: 430-435, ISSN: 1015-9770- Author Web Link
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- Citations: 58
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Journal articleThillai M, Eberhardt C, Lewin AM, et al., 2012,
Sarcoidosis and tuberculosis cytokine profiles: indistinguishable in bronchoalveolar lavage but different in blood
, PLoS One, Vol: 7, ISSN: 1932-6203BACKGROUND: The clinical, radiological and pathological similarities between sarcoidosis and tuberculosis can make disease differentiation challenging. A complicating factor is that some cases of sarcoidosis may be initiated by mycobacteria. We hypothesised that immunological profiling might provide insight into a possible relationship between the diseases or allow us to distinguish between them. METHODS: We analysed bronchoalveolar lavage (BAL) fluid in sarcoidosis (n = 18), tuberculosis (n = 12) and healthy volunteers (n = 16). We further investigated serum samples in the same groups; sarcoidosis (n = 40), tuberculosis (n = 15) and healthy volunteers (n = 40). A cross-sectional analysis of multiple cytokine profiles was performed and data used to discriminate between samples. RESULTS: We found that BAL profiles were indistinguishable between both diseases and significantly different from healthy volunteers. In sera, tuberculosis patients had significantly lower levels of the Th2 cytokine interleukin-4 (IL-4) than those with sarcoidosis (p = 0.004). Additional serum differences allowed us to create a linear regression model for disease differentiation (within-sample accuracy 91%, cross-validation accuracy 73%). CONCLUSIONS: These data warrant replication in independent cohorts to further develop and validate a serum cytokine signature that may be able to distinguish sarcoidosis from tuberculosis. Systemic Th2 cytokine differences between sarcoidosis and tuberculosis may also underly different disease outcomes to similar respiratory stimuli.
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Journal articleSharma S, Bandopadhyay R, Lashley T, et al., 2011,
LRRK2 expression in idiopathic and G2019S positive Parkinson's disease subjects: a morphological and quantitative study
, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol: 37, Pages: 777-790, ISSN: 0305-1846- Author Web Link
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- Citations: 35
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Journal articleParkkinen L, O'Sullivan SS, Kuoppamaki M, et al., 2011,
Does levodopa accelerate the pathologic process in Parkinson disease brain?
, NEUROLOGY, Vol: 77, Pages: 1420-1426, ISSN: 0028-3878- Author Web Link
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- Citations: 51
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Journal articleClayton LM, Devile M, Punte T, et al., 2011,
Retinal Nerve Fiber Layer Thickness in Vigabatrin-Exposed Patients
, ANNALS OF NEUROLOGY, Vol: 69, Pages: 845-854, ISSN: 0364-5134- Author Web Link
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- Citations: 38
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Journal articleCompta Y, Parkkinen L, O'Sullivan SS, et al., 2011,
Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important?
, BRAIN, Vol: 134, Pages: 1493-1505, ISSN: 0006-8950- Author Web Link
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- Citations: 402
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Journal articleFlouri E, Kallis C, 2011,
Adverse life events and mental health in middle adolescence
, JOURNAL OF ADOLESCENCE, Vol: 34, Pages: 371-377, ISSN: 0140-1971- Author Web Link
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- Citations: 15
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Journal articleJenkins T, Toosy AT, Ciccarelli O, et al., 2010,
Reply
, Annals of Neurology, Vol: 68, ISSN: 0364-5134
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