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@article{Lawlor:2020:10.1101/gad.336917.120,
author = {Lawlor, K and Marques-Torrejon, MA and Dharmalingham, G and El-Azhar, Y and Schneider, M and Pollard, S and Rodríguez, T and Rodriguez, T},
doi = {10.1101/gad.336917.120},
journal = {Genes and Development},
pages = {1599--1604},
title = {Glioblastoma stem cells induce quiescence in surrounding neural stem cells via Notch signalling},
url = {http://dx.doi.org/10.1101/gad.336917.120},
volume = {34},
year = {2020}
}

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TY  - JOUR
AB  - There is increasing evidence demonstrating that adult neural stem cells (NSCs) are a cell of origin of glioblastoma. Here we analyzed the interaction between transformed and wild-type NSCs isolated from the adult mouse subventricular zone niche. We found that transformed NSCs are refractory to quiescence-inducing signals. Unexpectedly, we also demonstrated that these cells induce quiescence in surrounding wild-type NSCs in a cell–cell contact and Notch signaling-dependent manner. Our findings therefore suggest that oncogenic mutations are propagated in the stem cell niche not just through cell-intrinsic advantages, but also by outcompeting neighboring stem cells through repression of their proliferation.
AU  - Lawlor,K
AU  - Marques-Torrejon,MA
AU  - Dharmalingham,G
AU  - El-Azhar,Y
AU  - Schneider,M
AU  - Pollard,S
AU  - Rodríguez,T
AU  - Rodriguez,T
DO  - 10.1101/gad.336917.120
EP  - 1604
PY  - 2020///
SN  - 0890-9369
SP  - 1599
TI  - Glioblastoma stem cells induce quiescence in surrounding neural stem cells via Notch signalling
T2  - Genes and Development
UR  - http://dx.doi.org/10.1101/gad.336917.120
UR  - http://hdl.handle.net/10044/1/84561
VL  - 34
ER  -