BibTex format
@article{Haltalli:2020:10.1038/s41556-020-00601-w,
author = {Haltalli, MLR and Watcham, S and Wilson, NK and Eilers, K and Lipien, A and Ang, H and Birch, F and Anton, SG and Pirillo, C and Ruivo, N and Vainieri, ML and Pospori, C and Sinden, RE and Luis, TC and Langhorne, J and Duffy, KR and Gottgens, B and Blagborough, AM and Lo, Celso C},
doi = {10.1038/s41556-020-00601-w},
journal = {Nature Cell Biology},
pages = {1399--1410},
title = {Manipulating niche composition limits damage to haematopoietic stem cells during Plasmodium infection},
url = {http://dx.doi.org/10.1038/s41556-020-00601-w},
volume = {22},
year = {2020}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Severe infections are a major stress on haematopoiesis, where the consequences for haematopoietic stem cells (HSCs) have only recently started to emerge. HSC function critically depends on the integrity of complex bone marrow (BM) niches; however, what role the BM microenvironment plays in mediating the effects of infection on HSCs remains an open question. Here, using a murine model of malaria and combining single-cell RNA sequencing, mathematical modelling, transplantation assays and intravital microscopy, we show that haematopoiesis is reprogrammed upon infection, whereby the HSC compartment turns over substantially faster than at steady-state and HSC function is drastically affected. Interferon is found to affect both haematopoietic and mesenchymal BM cells and we specifically identify a dramatic loss of osteoblasts and alterations in endothelial cell function. Osteo-active parathyroid hormone treatment abolishes infection-triggered HSC proliferation and—coupled with reactive oxygen species quenching—enables partial rescuing of HSC function.
AU - Haltalli,MLR
AU - Watcham,S
AU - Wilson,NK
AU - Eilers,K
AU - Lipien,A
AU - Ang,H
AU - Birch,F
AU - Anton,SG
AU - Pirillo,C
AU - Ruivo,N
AU - Vainieri,ML
AU - Pospori,C
AU - Sinden,RE
AU - Luis,TC
AU - Langhorne,J
AU - Duffy,KR
AU - Gottgens,B
AU - Blagborough,AM
AU - Lo,Celso C
DO - 10.1038/s41556-020-00601-w
EP - 1410
PY - 2020///
SN - 1465-7392
SP - 1399
TI - Manipulating niche composition limits damage to haematopoietic stem cells during Plasmodium infection
T2 - Nature Cell Biology
UR - http://dx.doi.org/10.1038/s41556-020-00601-w
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000592010900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - https://www.nature.com/articles/s41556-020-00601-w
VL - 22
ER -
