In this section
@article{Pfanzelter:2018:10.1083/jcb.201708091,
author = {Pfanzelter, J and Mostowy, S and Way, M},
doi = {10.1083/jcb.201708091},
journal = {J Cell Biol},
pages = {2911--2929},
title = {Septins suppress the release of vaccinia virus from infected cells.},
url = {http://dx.doi.org/10.1083/jcb.201708091},
volume = {217},
year = {2018}
}
TY - JOUR
AB - Septins are conserved components of the cytoskeleton that play important roles in many fundamental cellular processes including division, migration, and membrane trafficking. Septins can also inhibit bacterial infection by forming cage-like structures around pathogens such as Shigella We found that septins are recruited to vaccinia virus immediately after its fusion with the plasma membrane during viral egress. RNA interference-mediated depletion of septins increases virus release and cell-to-cell spread, as well as actin tail formation. Live cell imaging reveals that septins are displaced from the virus when it induces actin polymerization. Septin loss, however, depends on the recruitment of the SH2/SH3 adaptor Nck, but not the activity of the Arp2/3 complex. Moreover, it is the recruitment of dynamin by the third Nck SH3 domain that displaces septins from the virus in a formin-dependent fashion. Our study demonstrates that septins suppress vaccinia release by "entrapping" the virus at the plasma membrane. This antiviral effect is overcome by dynamin together with formin-mediated actin polymerization.
AU - Pfanzelter,J
AU - Mostowy,S
AU - Way,M
DO - 10.1083/jcb.201708091
EP - 2929
PY - 2018///
SP - 2911
TI - Septins suppress the release of vaccinia virus from infected cells.
T2 - J Cell Biol
UR - http://dx.doi.org/10.1083/jcb.201708091
UR - https://www.ncbi.nlm.nih.gov/pubmed/29921601
VL - 217
ER -
If you would like to become a member of the network please contact us.
Network Lead
Dr Michela Noseda
Network Lead
Dr Blerina Ahmetaj-Shala
Network Coordinator
Zuzanna Jablonska
Network Coordinator
Marine Secchi
General enquiries
ISRMNcontact@imperial.ac.uk
