Research

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Synthetic Biology underpins advances in the bioeconomy

Biological systems - including the simplest cells - exhibit a broad range of functions to thrive in their environment. Research in the Imperial College Centre for Synthetic Biology is focused on the possibility of engineering the underlying biochemical processes to solve many of the challenges facing society, from healthcare to sustainable energy. In particular, we model, analyse, design and build biological and biochemical systems in living cells and/or in cell extracts, both exploring and enhancing the engineering potential of biology. 

As part of our research we develop novel methods to accelerate the celebrated Design-Build-Test-Learn synthetic biology cycle. As such research in the Centre for Synthetic Biology highly multi- and interdisciplinary covering computational modelling and machine learning approaches; automated platform development and genetic circuit engineering ; multi-cellular and multi-organismal interactions, including gene drive and genome engineering; metabolic engineering; in vitro/cell-free synthetic biology; engineered phages and directed evolution; and biomimetics, biomaterials and biological engineering.

Publications

Citation

BibTex format

@article{Claesen:2017:10.1049/enb.2017.0019,
author = {Claesen, S and Stone, A and van, Rossum M and Kitney, RI},
doi = {10.1049/enb.2017.0019},
journal = {Engineering Biology},
pages = {100--102},
title = {Comprehensive web-based broker for bio-technology design and manufacturing},
url = {http://dx.doi.org/10.1049/enb.2017.0019},
volume = {1},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Synthetic biology, particularly in relation to characterisation experiments relating to the description of bio-parts frequently involves the use of a wide range of equipment, including, for example, plate reader's, flow cytometers, and mass spectrometers. This equipment is often from multiple manufacturers. The study describes broker technology that has been developed which has the ability to connect multiple types of equipment into a common information environment; the connectivity from the databases and equipment is achieved using Visbion's ‘cube’ technology that involves military specification encryption for data security. The broker technology uses a new, developing standard, Digital Imaging and Communication in Medicine (DICOM)-SB, that is based on the highly successful international standard for biomedicine, DICOM. The broker uses a version of the DICOM data model that has been specifically designed for synthetic biology and, in particular, characterisation data.
AU  - Claesen,S
AU  - Stone,A
AU  - van,Rossum M
AU  - Kitney,RI
DO  - 10.1049/enb.2017.0019
EP  - 102
PY  - 2017///
SN  - 2398-6182
SP  - 100
TI  - Comprehensive web-based broker for bio-technology design and manufacturing
T2  - Engineering Biology
UR  - http://dx.doi.org/10.1049/enb.2017.0019
UR  - http://hdl.handle.net/10044/1/59920
VL  - 1
ER  -
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