Research

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Synthetic Biology underpins advances in the bioeconomy

Biological systems - including the simplest cells - exhibit a broad range of functions to thrive in their environment. Research in the Imperial College Centre for Synthetic Biology is focused on the possibility of engineering the underlying biochemical processes to solve many of the challenges facing society, from healthcare to sustainable energy. In particular, we model, analyse, design and build biological and biochemical systems in living cells and/or in cell extracts, both exploring and enhancing the engineering potential of biology. 

As part of our research we develop novel methods to accelerate the celebrated Design-Build-Test-Learn synthetic biology cycle. As such research in the Centre for Synthetic Biology highly multi- and interdisciplinary covering computational modelling and machine learning approaches; automated platform development and genetic circuit engineering ; multi-cellular and multi-organismal interactions, including gene drive and genome engineering; metabolic engineering; in vitro/cell-free synthetic biology; engineered phages and directed evolution; and biomimetics, biomaterials and biological engineering.

Publications

Citation

BibTex format

@article{Boo:2021:10.1016/j.coisb.2021.100378,
author = {Boo, AR and Ledesma, Amaro R and Stan, G-B},
doi = {10.1016/j.coisb.2021.100378},
journal = {Current Opinion in Systems Biology},
pages = {1--14},
title = {Quorum sensing in synthetic biology: a review},
url = {http://dx.doi.org/10.1016/j.coisb.2021.100378},
volume = {28},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In nature, quorum sensing is one of the mechanism bacterial populations use to communicate withtheir own species or across species to coordinate behaviours. For the last 20 years, synthetic biologistshave recognised the remarkable properties of quorum sensing to build genetic circuits responsive topopulation density. This has led to progress in designing dynamic, coordinated and sometimes multicellular systems for bio-production in metabolic engineering and for increased spatial and temporalcomplexity in synthetic biology. In this review, we highlight recent works focused on using quorumsensing to engineer cell-cell behaviour.
AU  - Boo,AR
AU  - Ledesma,Amaro R
AU  - Stan,G-B
DO  - 10.1016/j.coisb.2021.100378
EP  - 14
PY  - 2021///
SN  - 2452-3100
SP  - 1
TI  - Quorum sensing in synthetic biology: a review
T2  - Current Opinion in Systems Biology
UR  - http://dx.doi.org/10.1016/j.coisb.2021.100378
UR  - https://www.sciencedirect.com/science/article/pii/S245231002100072X?via%3Dihub
UR  - http://hdl.handle.net/10044/1/91551
VL  - 28
ER  -
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