Research

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Synthetic Biology underpins advances in the bioeconomy

Biological systems - including the simplest cells - exhibit a broad range of functions to thrive in their environment. Research in the Imperial College Centre for Synthetic Biology is focused on the possibility of engineering the underlying biochemical processes to solve many of the challenges facing society, from healthcare to sustainable energy. In particular, we model, analyse, design and build biological and biochemical systems in living cells and/or in cell extracts, both exploring and enhancing the engineering potential of biology. 

As part of our research we develop novel methods to accelerate the celebrated Design-Build-Test-Learn synthetic biology cycle. As such research in the Centre for Synthetic Biology highly multi- and interdisciplinary covering computational modelling and machine learning approaches; automated platform development and genetic circuit engineering ; multi-cellular and multi-organismal interactions, including gene drive and genome engineering; metabolic engineering; in vitro/cell-free synthetic biology; engineered phages and directed evolution; and biomimetics, biomaterials and biological engineering.

Publications

Citation

BibTex format

@article{Kelwick:2015:10.1371/journal.pone.0117202,
author = {Kelwick, R and Kopniczky, M and Bower, I and Chi, W and Chin, MHW and Fan, S and Pilcher, J and Strutt, J and Webb, AJ and Jensen, K and Stan, G-B and Kitney, R and Freemont, P},
doi = {10.1371/journal.pone.0117202},
journal = {PLOS ONE},
title = {A Forward-Design Approach to Increase the Production of Poly-3-Hydroxybutyrate in Genetically Engineered <i>Escherichia coli</i>},
url = {http://dx.doi.org/10.1371/journal.pone.0117202},
volume = {10},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AU  - Kelwick,R
AU  - Kopniczky,M
AU  - Bower,I
AU  - Chi,W
AU  - Chin,MHW
AU  - Fan,S
AU  - Pilcher,J
AU  - Strutt,J
AU  - Webb,AJ
AU  - Jensen,K
AU  - Stan,G-B
AU  - Kitney,R
AU  - Freemont,P
DO  - 10.1371/journal.pone.0117202
PY  - 2015///
SN  - 1932-6203
TI  - A Forward-Design Approach to Increase the Production of Poly-3-Hydroxybutyrate in Genetically Engineered <i>Escherichia coli</i>
T2  - PLOS ONE
UR  - http://dx.doi.org/10.1371/journal.pone.0117202
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349789800019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - http://hdl.handle.net/10044/1/19331
VL  - 10
ER  -
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