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@article{Beard:2018:10.1039/c8cc01400k,
author = {Beard, R and Singh, N and Grundschober, C and Gee, AD and Tate, EW},
doi = {10.1039/c8cc01400k},
journal = {Chemical Communications},
pages = {8120--8123},
title = {High-yielding 18F radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo},
url = {http://dx.doi.org/10.1039/c8cc01400k},
volume = {54},
year = {2018}
}
TY - JOUR
AB - A novel Al18F labelled peptide tracer for PET imaging of oxytocin receptor has been accessed through a high radiochemical yield approach. This tracer showed comparable affinity and higher selectivity and stability compared to oxytocin, and was used to demonstrate direct nose-to-brain uptake following intranasal administration, a common yet controversial delivery route for oxytocin-based therapeutics.
AU - Beard,R
AU - Singh,N
AU - Grundschober,C
AU - Gee,AD
AU - Tate,EW
DO - 10.1039/c8cc01400k
EP - 8123
PY - 2018///
SN - 1359-7345
SP - 8120
TI - High-yielding 18F radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo
T2 - Chemical Communications
UR - http://dx.doi.org/10.1039/c8cc01400k
UR - http://hdl.handle.net/10044/1/60028
VL - 54
ER -
Prof. Ed Tate
GSK Chair in Chemical Biology
Department of Chemistry
Molecular Sciences Research Hub, White City Campus,
82 Wood Lane, London, W12 0BZ
e.tate@imperial.ac.uk
Tel: +44 (0)20 759 + ext 43752 or 45821