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@article{Kounde:2020:10.1039/D0CC00523A,
author = {Kounde, C and Shchepinova, M and Saunders, C and Muelbaier, M and Rackham, M and Harling, J and Tate, E},
doi = {10.1039/D0CC00523A},
journal = {Chemical Communications},
pages = {5532--5535},
title = {A caged E3 ligase ligand for PROTAC-mediated protein degradation with light},
url = {http://dx.doi.org/10.1039/D0CC00523A},
volume = {56},
year = {2020}
}
TY - JOUR
AB - With the intent of achieving greater spatiotemporal control of PROTAC-induced protein degradation, a light-activated degrader was designed by photocaging an essential E3 ligase binding motif in a BRD4 targeting PROTAC. Proteolysis was triggered only after a short irradiation time, the kinetics of which could be monitored by live-cell video microscopy.
AU - Kounde,C
AU - Shchepinova,M
AU - Saunders,C
AU - Muelbaier,M
AU - Rackham,M
AU - Harling,J
AU - Tate,E
DO - 10.1039/D0CC00523A
EP - 5535
PY - 2020///
SN - 1359-7345
SP - 5532
TI - A caged E3 ligase ligand for PROTAC-mediated protein degradation with light
T2 - Chemical Communications
UR - http://dx.doi.org/10.1039/D0CC00523A
UR - http://hdl.handle.net/10044/1/77762
VL - 56
ER -
Prof. Ed Tate
GSK Chair in Chemical Biology
Department of Chemistry
Molecular Sciences Research Hub, White City Campus,
82 Wood Lane, London, W12 0BZ
e.tate@imperial.ac.uk
Tel: +44 (0)20 759 + ext 43752 or 45821