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Citation

BibTex format

@article{Zhang:2022:10.1039/D2CC03092F,
author = {Zhang, Q and Kounde, C and Mondal, M and Zhang, L and Conole, D and De, Vita E and Fuchter, M and Tate, E},
doi = {10.1039/D2CC03092F},
journal = {Chemical Communications},
pages = {10933--10936},
title = {Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)},
url = {http://dx.doi.org/10.1039/D2CC03092F},
volume = {58},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Light-activable spatiotemporal control of PROTAC-induced protein degradation was achieved with novel arylazopyrazole photoswitchable PROTACs (AP-PROTACs). The use of a promiscuous kinase inhibitor in the design enables this unique photoswitchable PROTAC to selectively degrade four protein kinases together with on/off optical control using different wavelengths of light.
AU  - Zhang,Q
AU  - Kounde,C
AU  - Mondal,M
AU  - Zhang,L
AU  - Conole,D
AU  - De,Vita E
AU  - Fuchter,M
AU  - Tate,E
DO  - 10.1039/D2CC03092F
EP  - 10936
PY  - 2022///
SN  - 1359-7345
SP  - 10933
TI  - Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)
T2  - Chemical Communications
UR  - http://dx.doi.org/10.1039/D2CC03092F
UR  - http://pubs.rsc.org/en/content/articlehtml/2022/cc/d2cc03092f
UR  - http://hdl.handle.net/10044/1/99433
VL  - 58
ER  -
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Contact

Prof. Ed Tate
GSK Chair in Chemical Biology
Department of Chemistry
Molecular Sciences Research Hub, White City Campus,
82 Wood Lane, London, W12 0BZ

e.tate@imperial.ac.uk
Tel: +44 (0)20 759 + ext 43752 or 45821