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@article{Tomić:2024:10.1016/j.celrep.2024.114224,
author = {Tomi, G and Sheridan, C and Refermat, AY and Baggelaar, MP and Sipthorp, J and Sudarshan, B and Ocasio, CA and Suárez-Bonnet, A and Priestnall, SL and Herbert, E and Tate, EW and Downward, J},
doi = {10.1016/j.celrep.2024.114224},
journal = {Cell Reports},
title = {Palmitoyl transferase ZDHHC20 promotes pancreatic cancer metastasis},
url = {http://dx.doi.org/10.1016/j.celrep.2024.114224},
volume = {43},
year = {2024}
}
TY - JOUR
AB - Metastasis is one of the defining features of pancreatic ductal adenocarcinoma (PDAC) that contributes to poor prognosis. In this study, the palmitoyl transferase ZDHHC20 was identified in an in vivo short hairpin RNA (shRNA) screen as critical for metastatic outgrowth, with no effect on proliferation and migration in vitro or primary PDAC growth in mice. This phenotype is abrogated in immunocompromised animals and animals with depleted natural killer (NK) cells, indicating that ZDHHC20 affects the interaction of tumor cells and the innate immune system. Using a chemical genetics platform for ZDHHC20-specific substrate profiling, a number of substrates of this enzyme were identified. These results describe a role for palmitoylation in enabling distant metastasis that could not have been detected using in vitro screening approaches and identify potential effectors through which ZDHHC20 promotes metastasis of PDAC.
AU - Tomi,G
AU - Sheridan,C
AU - Refermat,AY
AU - Baggelaar,MP
AU - Sipthorp,J
AU - Sudarshan,B
AU - Ocasio,CA
AU - Suárez-Bonnet,A
AU - Priestnall,SL
AU - Herbert,E
AU - Tate,EW
AU - Downward,J
DO - 10.1016/j.celrep.2024.114224
PY - 2024///
SN - 2211-1247
TI - Palmitoyl transferase ZDHHC20 promotes pancreatic cancer metastasis
T2 - Cell Reports
UR - http://dx.doi.org/10.1016/j.celrep.2024.114224
UR - https://www.ncbi.nlm.nih.gov/pubmed/38733589
UR - http://hdl.handle.net/10044/1/112073
VL - 43
ER -