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Citation

BibTex format

@article{Yu:2012:10.1021/jm301160h,
author = {Yu, Z and Brannigan, JA and Moss, DK and Brzozowski, AM and Wilkinson, AJ and Holder, AA and Tate, EW and Leatherbarrow, RJ},
doi = {10.1021/jm301160h},
journal = {Journal of Medicinal Chemistry},
pages = {8879--8890},
title = {Design and Synthesis of Inhibitors of Plasmodium falciparum N-Myristoyltransferase, A Promising Target for Antimalarial Drug Discovery},
url = {http://dx.doi.org/10.1021/jm301160h},
volume = {55},
year = {2012}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Design of inhibitors for N-myristoyltransferase (NMT), an enzyme responsible for protein trafficking in Plasmodium falciparum, the most lethal species of parasites that cause malaria, is described. Chemistry-driven optimization of compound 1 from a focused NMT inhibitor library led to the identification of two early lead compounds 4 and 25, which showed good enzyme and cellular potency and excellent selectivity over human NMT. These molecules provide a valuable starting point for further development.
AU  - Yu,Z
AU  - Brannigan,JA
AU  - Moss,DK
AU  - Brzozowski,AM
AU  - Wilkinson,AJ
AU  - Holder,AA
AU  - Tate,EW
AU  - Leatherbarrow,RJ
DO  - 10.1021/jm301160h
EP  - 8890
PY  - 2012///
SN  - 0022-2623
SP  - 8879
TI  - Design and Synthesis of Inhibitors of Plasmodium falciparum N-Myristoyltransferase, A Promising Target for Antimalarial Drug Discovery
T2  - Journal of Medicinal Chemistry
UR  - http://dx.doi.org/10.1021/jm301160h
UR  - http://hdl.handle.net/10044/1/26844
VL  - 55
ER  -
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Contact

Prof. Ed Tate
GSK Chair in Chemical Biology
Department of Chemistry
Molecular Sciences Research Hub, White City Campus,
82 Wood Lane, London, W12 0BZ

e.tate@imperial.ac.uk
Tel: +44 (0)20 759 + ext 43752 or 45821