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Journal articleTate EW, 2008,
Recent advances in chemical proteomics: exploring the post-translational proteome
, Journal of Chemical Biology, Vol: 1, Pages: 1-1Identification and quantification of multiple proteins from complex mixtures is a central theme in post-genomic biology. Despite recent progress in high-throughput proteomics, proteomic analysis of post-translationally modified (PTM) proteins remains particularly challenging. This mini-review introduces the emerging field of chemical proteomics and reviews recent advances in chemical proteomic technology that are offering striking new insights into the functional biology of post-translational modification.
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Journal articleBowyer PW, Tate EW, Leatherbarrow RJ, et al., 2008,
<i>N</i>-myristoyltransferase:: a prospective drug target for protozoan parasites
, CHEMMEDCHEM, Vol: 3, Pages: 402-408, ISSN: 1860-7179- Author Web Link
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- Citations: 54
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Journal articleHeal WP, Wickramasinghe SR, Bowyer PW, et al., 2008,
Site-specific N-terminal labelling of proteins in vitro and in vivo using N-myristoyl transferase and bioorthogonal ligation chemistry
, Chem. Commun. -
Journal articleThongyoo P, Roque-Rosell N, Leatherbarrow RJ, et al., 2008,
Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides
, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol: 6, Pages: 1462-1470, ISSN: 1477-0520- Author Web Link
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- Citations: 124
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Journal articleBowyer PW, Gunaratne RS, Grainger M, et al., 2007,
Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of <i>Plasmodium falciparum</i>
, BIOCHEMICAL JOURNAL, Vol: 408, Pages: 173-180, ISSN: 0264-6021- Author Web Link
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- Citations: 55
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Journal articleThongyoo P, Jaulent AM, Tate EW, et al., 2007,
Immobilized protease-assisted synthesis of engineered cysteine-knot microproteins
, CHEMBIOCHEM, Vol: 8, Pages: 1107-1109, ISSN: 1439-4227- Author Web Link
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- Citations: 42
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Journal articleTate EW, 2006,
Chemical intervention in signalling networks: recent advances and applications
, Signal Transduction, Vol: 6, Pages: 144-159, ISSN: 1615-4053 -
Journal articleTate EW, Bowyer PW, Brown KA, et al., 2006,
Peptide-based inhibitors of N-myristoyl transferase generated from a lipid/combinatorial peptide chimera library
, Signal Transduction, Vol: 6, Pages: 160-166, ISSN: 1615-4053 -
Journal articleTate EW, Bowyer PW, Brown KA, et al., 2006,
Peptide-based inhibitors of N-myristoyl transferase generated from a lipid/combinatorial peptide chimera library
, Signal Transduction, Vol: 6, Pages: 160-166, ISSN: 1615-4053 -
Journal articleTate EW, Dixon DJ, Ley SV, 2006,
A highly enantioselective total synthesis of (+)- goniodiol
, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol: 4, Pages: 1698-1706, ISSN: 1477-0520- Author Web Link
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- Citations: 29
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