In this section
@article{Flack:2019:10.1021/acs.orglett.9b01115,
author = {Flack, T and Romain, C and White, A and Haycock, P and Barnard, A},
doi = {10.1021/acs.orglett.9b01115},
journal = {Organic Letters},
pages = {4433--4438},
title = {Design, synthesis and conformational analysis of oligobenzanilides as multi-facial alpha-helix mimetics},
url = {http://dx.doi.org/10.1021/acs.orglett.9b01115},
volume = {21},
year = {2019}
}
TY - JOUR
AB - The design, synthesis, and conformationalanalysis of an oligobenzanilide helix mimetic scaffold capableof simultaneous mimicry of two faces of an α-helix is reported.The synthetic methodology provides access to diversemonomer building blocks amenable to solid-phase assemblyin just four synthetic steps. The conformational flexibility ofmodel dimers was investigated using a combination of solidand solution state methodologies supplemented with DFTcalculations. The lack of noncovalent constraints allows forsignificant conformational plasticity in the scaffold, thuspermitting it to successfully mimic residues i, i+2, i+4, i+6, i+7, and i+9 of a canonical α-helix.
AU - Flack,T
AU - Romain,C
AU - White,A
AU - Haycock,P
AU - Barnard,A
DO - 10.1021/acs.orglett.9b01115
EP - 4438
PY - 2019///
SN - 1523-7052
SP - 4433
TI - Design, synthesis and conformational analysis of oligobenzanilides as multi-facial alpha-helix mimetics
T2 - Organic Letters
UR - http://dx.doi.org/10.1021/acs.orglett.9b01115
UR - https://pubs.acs.org/doi/10.1021/acs.orglett.9b01115
UR - http://hdl.handle.net/10044/1/71702
VL - 21
ER -
Dr Anna Barnard
Wellcome Trust Sir Henry Dale Fellow
Department of Chemistry
Imperial College London
Wood Lane
London W12 0BZ
a.barnard@imperial.ac.uk
Tel: +44 (0)20 7594 8551