@article{Haque:2023:10.1016/j.bmc.2023.117311,
author = {Haque, M and Flack, T and Singh, R and Wall, A and Vieira, de Castro G and Jiang, L and White, A and Barnard, A},
doi = {10.1016/j.bmc.2023.117311},
journal = {Bioorganic and Medicinal Chemistry},
title = {Aromatic oligoesters as novel helix mimetic scaffolds},
url = {http://dx.doi.org/10.1016/j.bmc.2023.117311},
volume = {87},
year = {2023}
}

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TY  - JOUR
AB  - The design, synthesis, and conformational analysis of a novel aromatic oligoester helix mimetic scaffold is reported. A range of amino acid-type side-chain functionality can be readily incorporated into monomer building blocks over three facile synthetic steps. Analysis of representative dimers revealed a stable conformer capable of effective mimicry of a canonical α-helix and the scaffold was found to be surprisingly stable to degradation in aqueous solutions at acidic and neutral pH.
AU  - Haque,M
AU  - Flack,T
AU  - Singh,R
AU  - Wall,A
AU  - Vieira,de Castro G
AU  - Jiang,L
AU  - White,A
AU  - Barnard,A
DO  - 10.1016/j.bmc.2023.117311
PY  - 2023///
SN  - 0968-0896
TI  - Aromatic oligoesters as novel helix mimetic scaffolds
T2  - Bioorganic and Medicinal Chemistry
UR  - http://dx.doi.org/10.1016/j.bmc.2023.117311
UR  - http://hdl.handle.net/10044/1/104264
VL  - 87
ER  - 

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