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@article{Yuan:2022:10.1007/s11095-022-03222-0,
author = {Yuan, T and Gao, L and Zhan, W and Dini, D},
doi = {10.1007/s11095-022-03222-0},
journal = {Pharmaceutical Research},
pages = {767--781},
title = {Effect of particle size and surface charge on nanoparticles diffusion in the brain white matter},
url = {http://dx.doi.org/10.1007/s11095-022-03222-0},
volume = {39},
year = {2022}
}
TY - JOUR
AB - PurposeBrain disorders have become a serious problem for healthcare worldwide. Nanoparticle-based drugs are one of the emerging therapies and have shown great promise to treat brain diseases. Modifications on particle size and surface charge are two efficient ways to increase the transport efficiency of nanoparticles through brain-blood barrier; however, partly due to the high complexity of brain microstructure and limited visibility of Nanoparticles (NPs), our understanding of how these two modifications can affect the transport of NPs in the brain is insufficient.MethodsIn this study, a framework, which contains a stochastic geometric model of brain white matter (WM) and a mathematical particle tracing model, was developed to investigate the relationship between particle size/surface charge of the NPs and their effective diffusion coefficients (D) in WM.ResultsThe predictive capabilities of this method have been validated using published experimental tests. For negatively charged NPs, both particle size and surface charge are positively correlated with D before reaching a size threshold. When Zeta potential (Zp) is less negative than -10 mV, the difference between NPs’ D in WM and pure interstitial fluid (IF) is limited.ConclusionA deeper understanding on the relationships between particle size/surface charge of NPs and their D in WM has been obtained. The results from this study and the developed modelling framework provide important tools for the development of nano-drugs and nano-carriers to cure brain diseases.
AU - Yuan,T
AU - Gao,L
AU - Zhan,W
AU - Dini,D
DO - 10.1007/s11095-022-03222-0
EP - 781
PY - 2022///
SN - 0724-8741
SP - 767
TI - Effect of particle size and surface charge on nanoparticles diffusion in the brain white matter
T2 - Pharmaceutical Research
UR - http://dx.doi.org/10.1007/s11095-022-03222-0
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000771331900003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR - https://link.springer.com/article/10.1007/s11095-022-03222-0
UR - http://hdl.handle.net/10044/1/111225
VL - 39
ER -