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@article{Bartolo:2024:10.3389/fbioe.2024.1410053,
author = {Bartolo, MK and Newman, S and Dandridge, O and Halewood, C and Accardi, MA and Dini, D and Amis, A},
doi = {10.3389/fbioe.2024.1410053},
journal = {Frontiers in Bioengineering and Biotechnology},
title = {An ovine knee simulator: description and proof of concept},
url = {http://dx.doi.org/10.3389/fbioe.2024.1410053},
volume = {12},
year = {2024}
}
TY - JOUR
AB - Aims: The ovine stifle is an established model for evaluation of knee treatments, such as meniscus replacement. This study introduces a novel ovine gait simulator for pre-testing of surgical treatments prior to in vivo animal trials. Furthermore, we describe a pilot study that assessed gait kinematics and contact pressures of native ovine stifle joints and those implanted with a novel fiber-matrix reinforced polyvinyl alcohol-polyethylene glycol (PVA-PEG) hydrogel meniscus to illustrate the efficacy of the simulator.Methods: The gait simulator controlled femoral flexion-extension and applied a 980N axial contact force to the distal tibia, whose movement was guided by the natural ligaments. Five right ovine stifle joints were implanted with a PVA-PEG total medial meniscus replacement, fixed to the tibia via transosseous tunnels and interference screws. Six intact and five implanted right ovine stifle joints were tested for 500 k gait cycles at 1.55 Hz. Implanted stifle joint contact pressures and kinematics in the simulator were compared to the intact group. Contact pressures were measured at 55° flexion using pressure sensitive film inserted sub-meniscally. 3D kinematics were measured optically across two 30-s captures.Results: Peak contact pressures in intact stifles were 3.6 ± 1.0 MPa and 6.0 ± 2.1 MPa in the medial and lateral condyles (p < 0.05) and did not differ significantly from previous studies (p > 0.4). Medial peak implanted pressures were 4.3 ± 2.2 MPa (p > 0.4 versus intact), while lateral peak pressures (9.4 ± 0.8 MPa) were raised post medial compartment implantation (p < 0.01). The range of motion for intact joints was flexion/extension 37° ± 1°, varus/valgus 1° ± 1°, external/internal rotation 5° ± 3°, lateral/medial translation 2 ± 1 mm, anterior/posterior translation 3 ± 1 mm and distraction/compression 1 ± 1 mm. Ovine joint kinematics in t
AU - Bartolo,MK
AU - Newman,S
AU - Dandridge,O
AU - Halewood,C
AU - Accardi,MA
AU - Dini,D
AU - Amis,A
DO - 10.3389/fbioe.2024.1410053
PY - 2024///
SN - 2296-4185
TI - An ovine knee simulator: description and proof of concept
T2 - Frontiers in Bioengineering and Biotechnology
UR - http://dx.doi.org/10.3389/fbioe.2024.1410053
UR - https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2024.1410053/full
UR - http://hdl.handle.net/10044/1/112907
VL - 12
ER -