BibTex format
@article{Pazoki:2018:10.1161/circulationaha.117.030898,
author = {Pazoki, R and Dehghan, A and Evangelou, E and Warren, H and Gao, H and Caulfield, M and Elliott, P and Tzoulaki, I},
doi = {10.1161/circulationaha.117.030898},
journal = {Circulation},
pages = {653--661},
title = {Genetic predisposition to high blood pressure and lifestyle factors. Associations with midlife blood pressure levels and cardiovascular events},
url = {http://dx.doi.org/10.1161/circulationaha.117.030898},
volume = {137},
year = {2018}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Background:High blood pressure (BP) is a major risk factor for cardiovascular diseases (CVDs), the leading cause of mortality worldwide. Both heritable and lifestyle risk factors contribute to elevated BP levels. We aimed to investigate the extent to which lifestyle factors could offset the effect of an adverse BP genetic profile and its effect on CVD risk.Methods:We constructed a genetic risk score for high BP by using 314 published BP loci in 277 005 individuals without previous CVD from the UK Biobank study, a prospective cohort of individuals aged 40 to 69 years, with a median of 6.11 years of follow-up. We scored participants according to their lifestyle factors including body mass index, healthy diet, sedentary lifestyle, alcohol consumption, smoking, and urinary sodium excretion levels measured at recruitment. We examined the association between tertiles of genetic risk and tertiles of lifestyle score with BP levels and incident CVD by using linear regression and Cox regression models, respectively.Results:Healthy lifestyle score was strongly associated with BP (P<10–320) for systolic and diastolic BP and CVD events regardless of the underlying BP genetic risk. Participants with a favorable in comparison with an unfavorable lifestyle (bottom versus top tertile lifestyle score) had 4.9, 4.3, and 4.1 mm Hg lower systolic BP in low, middle, and high genetic risk groups, respectively (P for interaction=0.0006). Similarly, favorable in comparison with unfavorable lifestyle showed 30%, 33%, and 31% lower risk of CVD among participants in low, middle, and high genetic risk groups, respectively (P for interaction=0.99).Conclusions:Our data further support population-wide efforts to lower BP in the population via lifestyle modification. The advantages and disadvantages of disclosing genetic predisposition to high BP for risk stratification needs careful evaluation.
AU - Pazoki,R
AU - Dehghan,A
AU - Evangelou,E
AU - Warren,H
AU - Gao,H
AU - Caulfield,M
AU - Elliott,P
AU - Tzoulaki,I
DO - 10.1161/circulationaha.117.030898
EP - 661
PY - 2018///
SN - 0009-7322
SP - 653
TI - Genetic predisposition to high blood pressure and lifestyle factors. Associations with midlife blood pressure levels and cardiovascular events
T2 - Circulation
UR - http://dx.doi.org/10.1161/circulationaha.117.030898
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000459428700002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - http://hdl.handle.net/10044/1/54016
VL - 137
ER -
