In this section
The Network aims to promote multi-disciplinary approaches to address challenging vaccine-related questions. This page contains a curated list of publications that highlight high-impact and collaborative approaches.
@article{So:2015:10.1139/cjm-2015-0166,
author = {So, EC and Mattheis, C and Tate, EW and Frankel, G and Schroeder, GN},
doi = {10.1139/cjm-2015-0166},
journal = {Canadian Journal of Microbiology},
pages = {617--635},
title = {Creating a customized intracellular niche: subversion of host cell signaling by Legionella type IV secretion system effectors},
url = {http://dx.doi.org/10.1139/cjm-2015-0166},
volume = {61},
year = {2015}
}
TY - JOUR
AB - The Gram-negative facultative intracellular pathogen Legionella pneumophila infects a wide range of different protozoa in the environment and also human alveolar macrophages upon inhalation of contaminated aerosols. Inside its hosts, it creates a defined and unique compartment, termed the Legionella-containing vacuole (LCV), for survival and replication. To establish the LCV, L. pneumophila uses its Dot/Icm type IV secretion system (T4SS) to translocate more than 300 effector proteins into the host cell. Although it has become apparent in the past years that these effectors subvert a multitude of cellular processes and allow Legionella to take control of host cell vesicle trafficking, transcription, and translation, the exact function of the vast majority of effectors still remains unknown. This is partly due to high functional redundancy among the effectors, which renders conventional genetic approaches to elucidate their role ineffective. Here, we review the current knowledge about Legionella T4SS effectors, highlight open questions, and discuss new methods that promise to facilitate the characterization of T4SS effector functions in the future.
AU - So,EC
AU - Mattheis,C
AU - Tate,EW
AU - Frankel,G
AU - Schroeder,GN
DO - 10.1139/cjm-2015-0166
EP - 635
PY - 2015///
SN - 1480-3275
SP - 617
TI - Creating a customized intracellular niche: subversion of host cell signaling by Legionella type IV secretion system effectors
T2 - Canadian Journal of Microbiology
UR - http://dx.doi.org/10.1139/cjm-2015-0166
VL - 61
ER -
Clinical Senior Lecturer
Dr Christopher Chiu
vaccine.network@imperial.ac.uk
+44 (0)20 8383 2301
