Publications

Search or filter publications

Search publications Search

Filter by type:

Filter by publication type

• Book
• Book chapter
• Conference paper
• Journal article
• Patent
• Report
• Software

Filter by year:

Filter from 202320222021202020192018 to Filter to 202320222021202020192018

---

Search results

• Journal article
  Pusey CD, Connor TM, Aiello V, Griffith M, Cairns T, Roufosse CH, Cook HTet al.,

  The natural history of IgM nephropathy in adults

  , Nephrology Dialysis Transplantation, ISSN: 1460-2385

  Background: Immunoglobulin M (IgM) nephropathy is an idiopathic glomerulonephritis characterised by diffuse mesangial deposition of IgM. IgM nephropathy has been a controversial diagnosis since it was first reported, and there are few data identifying specific pathological features that predict risk of progression of renal disease.Methods: We identified 57 cases of IgM nephropathy among 3220 adults undergoing renal biopsy at our institution. Biopsies had to satisfy the following three criteria to meet the definition of IgM nephropathy in this study: (1) dominant mesangial staining for IgM, (2) mesangial deposits on EM, (3) exclusion of systemic disease.Results: The median age was 42 years and 24 patients were male. 39% of patients presented with the nephrotic syndrome, 49% patients presented with non-nephrotic proteinuria, and 39% had eGFR <60 ml/min. Median post-biopsy follow-up was 40 months and serum creatinine had doubled in 31% by 5 years. Of histological parameters, glomerular sclerosis and tubular atrophy, but not mesangial proliferation, were risk factors for renal insufficiency. 39% of nephrotic patients achieved complete remission, and outcome was significantly worse in those who did not respond to treatment. FSGS was diagnosed in 80% of those undergoing repeat renal biopsy, despite ongoing mesangial IgM deposition. Conclusions: We propose criteria for a consensus definition of IgM nephropathy.

  • Abstract
  • Open Access Link
  • Cite
• Journal article
  Salama A, Ryba M, Levy J, Gaskin G, Pusey Cet al.,

  Long-term outcome of patients with severe ANCA associated vasculitis treated with plasmapheresis

  , CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, Vol: 25, Pages: S118-S118, ISSN: 0392-856X
  • Author Web Link
  • Cite
• Journal article
  Salama A, Pusey C, Jayne D, Mosley Ket al.,

  ABAVAS: A trial of CTLA4Ig in ANCA vasculitis

  , CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, Vol: 25, Pages: S114-S114, ISSN: 0392-856X
  • Author Web Link
  • Cite

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.